P801 - INVESTIGATING THE ASSOCIATION BETWEEN GESTATIONAL ANAEMIA AND ADVERSE PREGNANCY OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS.

P801

INVESTIGATING THE ASSOCIATION BETWEEN GESTATIONAL ANAEMIA AND ADVERSE PREGNANCY OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS.

I. P. A. das Virgens^1,*, Z. A. Balogh², N. Ács²

¹Centre for Translational Medicine, ²Department of Obstetrics and Gynaecology, Semmelweis University, Budapest, Hungary., Semmelweis University, Budapest, Hungary

Rationale: This systematic review and meta-analysis aimed to investigate the association between gestational anemia and its degrees of severity and pregnancy outcomes.

Methods: Data sources: a systematic search was conducted on PubMed, EMBASE, and Cochrane Library on November 16, 2022, following the recommendations of the Cochrane Handbook. The protocol for this systematic review was registered on PROSPERO (CRD42022370645). Study selection and data extraction: Studies evaluating pregnant patients with and without anaemia and the outcomes of interest (preterm birth (PTB), small for gestational age (SGA), intrauterine growth restriction (IUGR), miscarriages, stillbirth, neonatal mortality, or perinatal mortality) were eligible. Articles with an observational design reporting at least one of the outcomes were included. Severe anemia was defined as hemoglobin below 7 g/dL. Data from the eligible articles were extracted by two independent reviewers into an Excel sheet. Synthesis: The odds ratio (OR) was calculated with a 95% confidence interval (CI). Statistical heterogeneity across studies was assessed using the Cochrane Q test, and I² statistic. Random effects model with the Hartung-Knapp adjustment was used.

Results: A total of 201 studies were included in the qualitative synthesis, of which 96 studies reporting on the outcomes of over 20 million pregnant patients were included in the meta-analyses. Anaemia was associated with PTB (OR=1.49; CI:1.28–1.75) and neonatal mortality OR=1.25 (CI:1.07–1.47). Severe anaemia was associated with PTB (OR=3.43; CI:2.17–5.41), IUGR (OR=2.48; CI:1.28-4.82), stillbirth (OR=3.13; CI: 2.12-4.62), neonatal mortality (OR=4.79; CI:2.28–10.06), and perinatal mortality (OR=3.66; CI: 2.75–4.88).

Conclusion: Patients with severe anaemia have significantly higher odds for PTB, SGA, IUGR, and perinatal mortality compared to those with no anemia.

Disclosure of Interest: None declared