LB082 - EFFECTS OF A DIABETES-SPECIFIC FORMULA ON POSTPRANDIAL GUT HORMONE RESPONSES IN INDIVIDUALS WITH TYPE 2 DIABETES: RESULTS FROM A RANDOMIZED CROSSOVER TRIAL

LB082

EFFECTS OF A DIABETES-SPECIFIC FORMULA ON POSTPRANDIAL GUT HORMONE RESPONSES IN INDIVIDUALS WITH TYPE 2 DIABETES: RESULTS FROM A RANDOMIZED CROSSOVER TRIAL

S. T. Kong^1,*, D. Huynh¹, N. Mustafa², Q. Yao³, L. Wong¹, G. Baggs³, S. L. Tey¹

¹Abbott Nutrition Research and Development, Singapore, Singapore, ²Department of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia, ³Abbott Nutrition Research and Development, Columbus, Ohio, United States

Rationale: Studies have shown that diabetes-specific formulas (DSF) improve glycemic response compared to common breakfasts. To elucidate the benefits DSF on satiety and hunger, beyond glycemic management, this study investigated its effect on postprandial gut hormone responses.

Methods: Ninety-two adults with type 2 diabetes (T2D) (18.5<BMI≤35.0 kg/m², 7≤HbA1c<10%) received DSF, rice porridge and bread with jam, in a randomized, crossover study. Individuals with complete records and blood samples (n=82) were included in this analysis. Eight gut hormones were analyzed: glucagon-like peptide 1 (GLP-1), peptide YY (PYY), glucagon, C-peptide, amylin, glucose-dependent insulinotropic peptide (GIP), ghrelin, and leptin. The positive or negative area under the curve (pAUC or nAUC) from 0 to 240 min (pg/ml.min) for each hormone was compared among treatments.

Results: The glucose and insulin pAUCs were significantly lower in DSF compared to porridge and bread, and were published previously (all p≤0.007) [1]. In this analysis, GLP-1 pAUC in DSF was almost twice as high as in bread (p<0.001) and trended higher compared to porridge (p=0.069). Glucagon and PYY pAUCs were also significantly higher in DSF compared to porridge and bread (all p<0.001). C-peptide and amylin, which are co-secreted with insulin, had significantly lower pAUCs with DSF compared to porridge and bread (all p≤0.036). There were no significant differences in pAUC of GIP, and nAUCs of ghrelin and leptin between any of the treatments (all p≥0.200).

Conclusion: DSF significantly reduced glucose, insulin, C-peptide and amylin pAUCs, while increasing satiety hormones such as GLP-1, PYY, and glucagon pAUCs compared to common breakfasts. In addition to good glycemic control, DSF helps manage satiety and hunger and can be a healthful breakfast option in individuals with T2D.

References: [1] Tey SL, et al. Clin Nutr ESPEN. 2023;58:735

Disclosure of Interest: None declared