PP364 - SARCOPENIC COMPONENTS IN END STAGE OSTEOARTHRITIS: WHEN JOINT INFLAMMATION MEETS MUSCLE FUNCTION DECLINE

PP364

SARCOPENIC COMPONENTS IN END STAGE OSTEOARTHRITIS: WHEN JOINT INFLAMMATION MEETS MUSCLE FUNCTION DECLINE

M. J. Spanoudaki^1,*, C. Giaginis², A. T. Cheimars¹, D. Georgianos³, S. Pellios⁴, N. A. Tsitlakidoy⁵, M. Chatzidimitiou⁶, S. K. Papadopoulou¹

¹Nutritional Sciences and Dietetics, International Hellenic University, Sindos Thessaloniki, ²2Department of Food Science and Nutrition , University of Aegean, Mirina Limnos, ³Second Orthopedic Clinic, ⁴First Orthopedic Clinic, 424 General Military Hospital, ⁵Dietetics, Aegean College-Essex University, Thessaloniki, ⁶Department of Biomedical Science, International Hellenic University, Sindos Thessaloniki, Greece

Rationale: End-stage osteoarthritis (OA) severely restricts daily activities and physical function, reflecting a complex muscle-joint interplay. This study investigated sarcopenic components and the sarcopenic profile in patients with end-stage lower-limb OA.

Methods: 88 older adults (61 female, 27 male, mean age: 66.4±11.4 years) with end-stage knee or hip OA were assessed. Handgrip strength (HGS) was measured by digital dynamometry and body composition by BIA. Appendicular skeletal muscle mass (ASMM) was normalized by BMI (ASMM/BMI) and height squared. Participants completed SARC-F, MedDietScore, and SarQoL. Functional tests included 4m gait speed and 5-repetition chair-stand. Serum CRP and urinary isoprostanes were measured. Statistics included t-tests vs. EWGSOP2 cut-offs, Pearson correlations, and stepwise regression to identify HGS predictors (p<0.05).

Results: Low HGS was prevalent in 51.9% of men and 42.6% of women. Mean SARC-F was 4.17, indicating significant clinical risk for sarcopenia (p=0.048). Regression identified ASMM/BMI as the only independent predictor of HGS, explaining 49.9% of variance (Adj. R2=0.499, p<0.001). Phase Angle, CRP, and urinary isoprostanes did not enter the model (p>0.05). MedDietScore correlated with lower CRP (r=-0.213, p=0.047). ASMM/BMI correlated positively with gait speed (r=0.512, p<0.001) and SarQoL score (r=0.227, p=0.033)

Conclusion: High functional impairment prevalence in end-stage OA reflects the muscle-joint-inflammation impact on quality of life. ASMM/BMI strongly predicts HGS. Mediterranean diet adherence was linked to lower systemic inflammation,suggesting that nutritional interventions are pivotal for managing inflammatION and preserving functionality.

References: Cruz-Jentoft AJ, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31. doi:10.1093/ageing/afy169

Disclosure of Interest: None declared