Sep 5, 2026
2:00 PM12:00 PM
ePoster display
GENERALIZED STRUCTURAL EQUATION MODELLING STUDY ON COMMON MENTAL DISORDERS, METABOLIC SYNDROME, BODY COMPOSITION, INFLAMMATION, GUT PERMEABILITY, AND LIFESTYLE
Marcela Larissa COSTA
PD640
GENERALIZED STRUCTURAL EQUATION MODELLING STUDY ON COMMON MENTAL DISORDERS, METABOLIC SYNDROME, BODY COMPOSITION, INFLAMMATION, GUT PERMEABILITY, AND LIFESTYLE
J. Valentini Neto1,2, M. L. Costa1,*, A. Almeida Bastos1, L. Nascimento Maximiano Ferreira1, M. Macedo Rogero1, R. M. Fisberg1
1Nutrition Department, 2School of Arts, Science and Humanities, University of São Paulo, São Paulo, Brazil
Rationale: Noncommunicable diseases (NCDs) and Common Mental Disorders (CMD) are highly prevalent worldwide. Metabolic Syndrome (MS), characterized by metabolic disturbances, is closely linked to NCDs. CMD and NCD may share development pathways, including inflammation, gut permeability, and body composition. To explore direct and indirect associations between CMD, MS, body composition, inflammation, gut permeability, and lifestyle factors (diet and physical activity) in individuals aged 40+.
Methods: Secondary analysis of a convenience subsample (n=197) from a larger study. CMD was assessed using the Self Report Questionnaire-20. MS was identified by meeting three or more criteria: waist circumference, HDL levels, triacylglycerol, blood pressure, and fasting blood glucose. Gut permeability and systemic inflammation scores (GPS; SIS) were calculated using normalized marker values. Anthropometric measures included height, body mass, waist circumference, appendicular skeletal muscle mass (ASMM), and total body fat mass, measured via DXA.
Results: Direct and indirect associations were identified: dietary inflammatory index (DII) influenced CMD and MS through ASMM; total body fat impacted MS via SIS; and GPS influenced MS through total body fat and SIS.
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Conclusion: DII and body composition are linked to inflammation and gut permeability, which are associated with MS and CMD. Inflammation appears to mediate these relationships.
Disclosure of Interest: None declared