PD164 - TOLERABILITY AND ACCEPTABILITY OF A HIGH-PROTEIN, LOW-VOLUME ORAL NUTRITIONAL SUPPLEMENT ACROSS TWO PROSPECTIVE STUDIES

PD164

TOLERABILITY AND ACCEPTABILITY OF A HIGH-PROTEIN, LOW-VOLUME ORAL NUTRITIONAL SUPPLEMENT ACROSS TWO PROSPECTIVE STUDIES

C.-J. Jones¹, M. Lindsay^1,*, A. Johnson², S. Medlin³, M. Creese⁴, E. Trioulet⁴, J. Maldonado⁴, K. Purchase⁴, S. Muldowney⁴

¹R&D, AYMES International Ltd, Leek , ²Weight with Alice, Hereford, ³City Dietitians, London, ⁴AYMES International Ltd, Leek , United Kingdom

Rationale: Disease-related malnutrition (DRM) affects up to 3 million people in the UK¹. High-protein, low-volume oral nutritional supplements (ONS) may improve compliance and nutritional outcomes³, but continued evidence on their tolerability and acceptability at one and two servings daily is needed.

Methods: Two prospective, single-arm, longitudinal, multicentre studies evaluated ActaGain Protein Compact (AYMES International; 125ml, 2.6kcal/ml, 20g protein/bottle) in adults with or at risk of DRM. Study 1 (n=16; 28 days; 1 serving/day); assessed gastrointestinal (GI) tolerance, palatability and compliance. Study 2 (n=10; 7 days; 2 servings/day) captured GI symptoms at baseline and day 7. Compliance was calculated as a percentage of the prescribed volume consumed.

Results: Across both studies (n=26), 100% of participants found the product acceptable overall. Study 1: 94% mean compliance with no GI symptoms attributed to the product, 100% rated taste, consistency and convenience acceptable. Study 2: mean compliance 86% (7/10 achieving 100%); 8/10 (80%) showed stable or improved GI tolerance, with all clinicians having no concerns regarding the tolerance and compliance of the product. Palatability was rated positively across all five flavours, with 100% rating volume adequate and convenience acceptable.

Conclusion: Conclusions: Across 26 adults with a variety of complex medical conditions, the supplement demonstrated consistent tolerability, high compliance and strong palatability at both one and two servings daily, supporting its use as a suitable ONS for adults with or at risk of DRM.

References: 1. Russell CA, Elia M. Malnutrition in the UK: where does it begin? Proc Nutr Soc. 2010;69(4):465-9. 2. Hubbard GP, Elia M, Holdoway A, Stratton RJ. A systematic review of compliance to oral nutritional supplements. Clin Nutr. 2012;31(3):293-312. doi: 10.1016/j.clnu.2011.11.020

Disclosure of Interest: C.-J. Jones Other: is an employee of AYMES International Ltd., the manufacturer of the study product., M. Lindsay Other: is an employee of AYMES International Ltd., the manufacturer of the study product., A. Johnson Grant / Research Support from: This study was funded by AYMES International Ltd. Alice Johnson received funding from AYMES International Ltd. to conduct this research, S. Medlin Grant / Research Support from: This study was funded by AYMES International Ltd. City Dietitians received funding from AYMES International Ltd. to conduct this research, M. Creese Other: is an employee of AYMES International Ltd., the manufacturer of the study product., E. Trioulet Other: is an employee of AYMES International Ltd., the manufacturer of the study product., J. Maldonado Other: is an employee of AYMES International Ltd., the manufacturer of the study product., K. Purchase Other: is an employee of AYMES International Ltd., the manufacturer of the study product., S. Muldowney Other: is an employee of AYMES International Ltd., the manufacturer of the study product.