P870 - GENERAL AND VISCERAL ADIPOSITY INDICES AND THE RISK OF CARDIOVASCULAR DISEASE AND MORTALITY: A PROSPECTIVE COHORT STUDY

P870

GENERAL AND VISCERAL ADIPOSITY INDICES AND THE RISK OF CARDIOVASCULAR DISEASE AND MORTALITY: A PROSPECTIVE COHORT STUDY

M. Golzarand^1,*, P. Mirmiran², F. Azizi³

¹Nutrition and Endocine Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, ²Nutrition and Endocrine Research Center, ³Endocrine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic Of

Rationale: Studies revealed that adiposity, especially abdominal adiposity, is a better predictor of health risks than obesity. The current techniques to examine adiposity are high-cost, so there is a need for low-cost yet highly accurate alternative methods. In recent years, some novel anthropometric indices, including Body Adiposity Estimator (BAE) index and visceral adiposity index (VAI), have been introduced. Therefore, the present longitudinal research aimed to assess the association between VAI and BAE index and the risk of cardiovascular disease (CVD) and mortality among Iranian adults.

Methods: We included 11,394 eligible individuals aged older than 18 years who enrolled in the first phase of the Tehran Lipid and Glucose Study (1999-2001) and new participants who enrolled in the second phase (2002-2005) in this study and were followed until 2018. Reliable medical data were used to evaluate CVD and mortality. The Cox proportional hazards model was used to assess the general and visceral adiposity indices and the risk of CVD and mortality.

Results: During the 15.7 years of follow-up, 1612 cases of CVD, 1074 cases of all-cause deaths were recorded. Our results indicated that each unit increase in BAE was associated with a 22% higher risk of CVD (HR: 1.22; 95% CI: 1.09-1.38). Interestingly, we found an inverse association between this index and all-cause (HR: 0.86; 95% CI: 0.75-0.98) and cancer mortality (HR: 1.01; 95% CI: 0.80-1.27) but not CVD mortality (HR: 0.72; 95% CI: 0.54-0.96). There was no significant relationship between VAI and outcomes of interest.  

Conclusion: Our findings revealed a positive association between general adiposity and CVD but not visceral adiposity. In addition, we observed an inverse link between general adiposity and mortality and cancer mortality. Further longitudinal cohort study is needed to conclusive decision.

Disclosure of Interest: M. Golzarand Grant / Research Support from: I have no conflict of interest, Consultant for: I have no conflict of interest, Speakers Bureau of: I have no conflict of interest, Shareholder of: I have no conflict of interest, Paid Instructor at: I have no conflict of interest, Other: I have no conflict of interest, P. Mirmiran: None declared, F. Azizi: None declared