PT10. - PHASE ANGLE TRAJECTORY AMONG CRITICAL CARE PATIENTS: LONGITUDINAL DECLINE PREDICTS MORTALITY INDEPENDENT OF CLINICAL SEVERITY SCORES.

PT10.

PHASE ANGLE TRAJECTORY AMONG CRITICAL CARE PATIENTS: LONGITUDINAL DECLINE PREDICTS MORTALITY INDEPENDENT OF CLINICAL SEVERITY SCORES.

P. Papanastasiou¹, S. Chaloulakou¹, D. Karayiannis^1,*, G. Poupouzas², V. Issaris², E. Jahaj², C. Vrettou², A. Vassiliou², I. Dimopoulou²

¹Clinical Nutrition, ²1st Department of Critical Care Medicine, School of Medicine, National andKapodistrian University of Athens, Evaggelismos General Hospital, Athens, Greece

Rationale: Phase angle (PhA) is an emerging biomarker that reflects cellular integrity and nutritional status. In this study, we explored the potential associations between PhA, clinical severity scores, and survival outcomes within 60 days of Intensive Care Unit (ICU) admission. 

Methods: A single-center prospective analysis was conducted on 43 critically ill patients admitted to Evaggelismos General Hospital ICU between May and November 2024. Patients were stratified by PhA (≤5.4° vs. >5.4°), and SOFA and APACHE scores were recorded. Demographic, anthropometric, and metabolic parameters were analyzed using independent t-tests and Mann-Whitney U tests. Longitudinal changes in PhA were assessed with Durbin-Conover pairwise comparisons, and survival outcomes were evaluated using Kaplan-Meier and Cox proportional hazards analyses.

Results: At admission, the mean age of patients was 54.6 ± 17 years, and 63.6% were male. Patients with PhA >5.4° were significantly younger (p < 0.001) and exhibited lower body fat (p = 0.008), higher fat-free mass, larger calf circumference, and higher resting energy expenditure per kilogram of body weight (REE/kg) (27.4 vs. 23.1, p = 0.002). PhA demonstrated a steady decline over time, with median values decreasing from 5.45 at baseline to 5.15 at the final measurement (p < 0.001). Kaplan-Meier analysis revealed significantly reduced 60 day survival in patients with lower PhA (HR: 6.32, p = 0.032). Multivariable Cox regression analysis showed that PhA values ≤5.4° were independently associated with higher mortality risk after adjusting for sepsis, SOFA scores, and gender (HR: 18.70, p = 0.012).

Conclusion: In this single center study, lower PhA at ICU admission and its decline over time was associated with higher mortality risk, independent of clinical severity scores. 

Disclosure of Interest: None declared