PD212 - GENE-DIET INTERACTION BETWEEN BUD13-ZNF259-APOA5 GENE CLUSTER POLYMORPHISM AND VITAMIN E STATUS ON LIPID PROFILE IN A HIGHLY ADMIXED BRAZILIAN POPULATION

PD212

GENE-DIET INTERACTION BETWEEN BUD13-ZNF259-APOA5 GENE CLUSTER POLYMORPHISM AND VITAMIN E STATUS ON LIPID PROFILE IN A HIGHLY ADMIXED BRAZILIAN POPULATION

M. L. Costa^1,*, M. Macedo Rogero¹, C. Hermes Sales¹, F. Mori Sarti¹, R. M. Fisberg¹

¹Nutrition Department, University of São Paulo, São Paulo, Brazil

Rationale: In admixed populations, the relationship between α-tocopherol and cardiovascular risk remains poorly understood. The rs964184 (BUD13-ZNF259-APOA5 cluster) variant may affect vitE status and lipid profiles. We evaluated whether the vitE/lipid ratio is associated with lipid profile and whether rs964184 modulates these associations.

Methods: We analyzed 518 adults and older adults from ISA-Nutrition. Plasma α-tocopherol was measured by HPLC and expressed relative to total lipids. rs964184 was genotyped (MAF=0.22; HWE p>0.05). Lipids were classified per AHA criteria. Diet was assessed by 24-h recalls. Associations were examined using adjusted logistic regression and two-way ANOVA.

Results: Significant gene-diet interactions were observed between rs964184 and vitE/lipids. In the CC genotype, vitE/lipid showed a protective effect, reducing the odds of elevated total cholesterol (TC) by 37% and LDL-c by 33%. However, this result was lost in CG, where each unit increase in vitE/lipids was associated with 1.46-fold higher odds of TC and 1.66-fold higher odds of LDL-c compared with the CC individual. Stratified analysis confirmed that CC individuals with normal lipid profiles had higher vitE/lipids compared to those with elevated lipid profiles (TC: 3.21 vs 2.78, p=0.036; LDL-c: 3.19 vs 2.79, p=0.013), a result absent in G carriers. No significant interactions were observed for triglycerides, HDL-c, non-HDL-c, or VLDL-c.

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Conclusion: The rs964184 genotype modulates the response to vitamin E, with potential protective effects in CC homozygotes that may be absent in G-allele carriers. These findings highlight the role of genetic background in vitamin E activity and support personalized nutritional strategies.

References: Blumenthal RS, Morris PB, Gaudino M, Johnson HM, Anderson TS, et al. 2026 ACC/AHA guideline on the management of dyslipidemia. Circulation. 2026.

Disclosure of Interest: None declared