LB018 - OSTEOPOROSIS IN TYPE 2 DIABETES.

LB018

OSTEOPOROSIS IN TYPE 2 DIABETES.

A. Moldobaeva^1,2,* on behalf of Saltanat Abazbekova

¹Propedtherapy and family medicine, ²International Higher School of medicine, Bishkek, Kyrgyzstan

 

Rationale: To determine the prevalence of osteopenia and osteoporosis among patients with T2DM.

Methods: Fifty patients with confirmed T2DM were enrolled.Dual-energy X-ray absorptiometry (DEXA) of the lumbar spine,hip and forearm was performed. Laboratory assessments included glucose, HbA1c,vitamin D, parathyroid hormone(PTH),calcium,phosphorus,alkaline phosphatase,and creatinine.Correlation analyses were conducted to identify associations between laboratory parameters and lumbar spine BMD.

Results: The mean age of participants was 62.6 ± 8.25 years, and mean BMI was 29.4 ± 4.88 kg/m². Osteopenia was detected in 46.9% and osteoporosis in 32.7% of patients; only approximately 20% had normal BMD. No significant correlations were observed between lumbar BMD and HbA1c (r = 0.027, p = 0.853) or vitamin D levels (r = 0.124, p = 0.402). PTH demonstrated a significant negative correlation with lumbar BMD (r = −0.363, p = 0.010).

Conclusion: Reduced BMD was highly prevalent among patients with T2DM.Elevated PTH levels were associated with lower lumbar BMD,highlighting the potential role of secondary hyperparathyroidism in diabetic bone loss and supporting routine bone health assessment in T2DM patients.

References:         1. Khosla S. Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus. Nat Rev Endocrinol. 2021;17:685–697.

        2. Qiu J. Is diabetes mellitus a risk factor for low bone density: a systematic review and meta-analysis. BMC Endocr Disord. 2021;21:65.

        3. Sheu A. Assessment and treatment of osteoporosis and fractures in type 2 diabetes. Trends Endocrinol Metab. 2022;33(5):333–344.

        4. Pal R, Prasad TN, Bhadada SK. Bone fragility in type 2 diabetes mellitus: a lot left to explore. Nat Rev Endocrinol. 2022;18:651.

        5. Romero-Díaz C, Duarte-Montero D, Gutiérrez-Romero SA, Mendivil CO. Diabetes and bone fragility. Diabetes Ther. 2021;12:71–86.

        6. Lee HS, Hwang JS. Impact of type 2 diabetes mellitus and antidiabetic medications on bone metabolism. Curr Diab Rep. 2020;20(12):78.

 

Disclosure of Interest: A. Moldobaeva Other: We declare conflict of interest