PD196 - IMPACT OF VITAMIN D SUPPLEMENTATION ON LDL AND NON-HDL CHOLESTEROL IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES: DATA FROM A CONTROLLED CLINICAL TRIAL

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PD196

IMPACT OF VITAMIN D SUPPLEMENTATION ON LDL AND NON-HDL CHOLESTEROL IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES: DATA FROM A CONTROLLED CLINICAL TRIAL

B. F. Nascimento1, J. Braga1, B. B. de Araújo1, I. Pimentel1, W. Peres1, P. Padilha1,*

1UFRJ, Rio de Janeiro, Brazil

 

Rationale: Type 1 Diabetes Mellitus (T1DM) in childhood is associated with increased cardiovascular risk, with dyslipidemia as a major contributing factor. Vitamin D has been proposed as a potential adjuvant therapy due to its anti-inflammatory properties. However, evidence regarding its effects on atherogenic lipoproteins, such as LDL-cholesterol and non-HDL cholesterol, in pediatric T1DM remains limited. This study aimed to evaluate the effect of vitamin D supplementation on LDL- and non-HDL cholesterol in children and adolescents with T1DM.

Methods: This controlled clinical trial included children and adolescents aged 7–16 years with T1DM for at least 1 year. Participants with vitamin D deficiency [25(OH)D <30 ng/mL] were allocated to the intervention group. They received oral cholecalciferol (2000 IU/day) for 12 weeks, while those with levels>30 ng/mL comprised the control group. Sociodemographic, clinical, laboratory, anthropometric, and lifestyle data were collected. LDL-cholesterol and non-HDL cholesterol were assessed at baseline and after intervention. Statistical analyses included paired t-tests, Pearson correlation, and Glass’s Delta, with a significance level of 5%.

Results: A total of 121 participants were evaluated (mean age 11.4 ± 2.18 years), 48,8% female, with a high prevalence of vitamin D deficiency (78.5%). Dyslipidemia was present in 63.6% at baseline. No significant changes were observed in LDL-cholesterol or non-HDL cholesterol after 12 weeks of supplementation. Vitamin D levels increased significantly, but no effect was observed on atherogenic lipoproteins.

Conclusion: Vitamin D supplementation (2000 IU/day for 12 weeks) did not improve LDL-cholesterol or non-HDL cholesterol in children and adolescents with T1DM. Although effective in correcting deficiency, it does not appear to modify atherogenic lipid fractions in the short term.

Disclosure of Interest: None declared