O064 - CIRCADIAN EATING WITH REGULATED CARBOHYDRATE INTAKE: A SOMATOTYPE-SPECIFIC STRATEGY TO REDUCE INFLAMMAGING AND SLOW BIOLOGICAL AGING IN OBESE ADULTS

O064

CIRCADIAN EATING WITH REGULATED CARBOHYDRATE INTAKE: A SOMATOTYPE-SPECIFIC STRATEGY TO REDUCE INFLAMMAGING AND SLOW BIOLOGICAL AGING IN OBESE ADULTS

T. Soukup^1,*, D. Holmannova¹, M. Hanzlova¹, T. Svadlakova^1,2, C. Andrys², P. Borsky¹, V. Blaha³, M. Koutnikova¹, M. Kubickova³, L. Borska¹

¹Department of Preventive Medicine, Faculty of Medicine in Hradec Kralove, ²Department of Clinical Immunology and Allergology, ³The 3rd Department of Internal Medicine – Metabolic Care and Gerontology, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic

Rationale: Obesity is a complex, global health issue requiring integrated dietary and lifestyle strategies. Chronic low-grade inflammation and accelerated biological aging are key targets for intervention. We hypothesized that circadian eating combined with controlled carbohydrate intake could reduce systemic inflammation and improve aging biomarkers, with varying effects based on somatotype.

Methods: In a three-month pilot study, 37 obese adults followed a circadian eating regimen involving an 11-hour eating window with regulated carbohydrate intake. Somatotypes were assessed, and adherence to the dietary plan tracked. Outcomes included BMI, waist circumference, lipid profiles, inflammatory markers (CRP, IL-6), and biological age measures (Phenoage, Anthropoage, Glycanage, telomere length).

Results: Significant improvements were seen in biological age (median 46→36 yrs, p = 0.028, r = -0.4), BMI (35→33, p < 0.001, r = -0.9), waist (113→102 cm, p < 0.001, r = -0.8), TAG (p = 0.005, r = -0.5), LDL (p = 0.018, r = -0.4), CRP (p = 0.041), and IL-6 (p = 0.039). Endomorphs with low adherence showed telomere loss and worsening of aging markers; meso-/ectomorphs showed biomarker stability. Regular physical activity was associated with protective effects, mitigating the negative impacts of inconsistent dietary adherence.

Conclusion: Somatotype-specific circadian eating may reduce inflammaging and decelerate biological aging in obesity. Personalized nutrition could be a key tool for clinical obesity management and healthy aging.

Disclosure of Interest: None declared