P757 - ULTRASONOGRAPHY OF MUSCLE MASS ASSESSMENT FOR SARCOPENIA DIAGNOSIS IN HEMODIALYSIS PATIENTS

P757

ULTRASONOGRAPHY OF MUSCLE MASS ASSESSMENT FOR SARCOPENIA DIAGNOSIS IN HEMODIALYSIS PATIENTS

Y. Onishi^1,2,*, N. Kobayashi³, D. Kadowaki⁴, H. Ishihara⁴, T. Yokoyama⁴, T. Mifune⁴, Y. Aga⁵, M. Onishi³, I. Nojima^1,2, H. Morinaga^1,2, H. A. Uchida², J. Wada²

¹Department of Comprehensive Therapy for Chronic Kidney Disease, ²Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences, ³General Medicine, ⁴Division of Hemodialysis, ⁵Division of Nutrition, Okayama Saidaiji Hospital, Okayama, Japan

Rationale: Sarcopenia is diagnosed based on decreased muscle strength, reduced physical function, and loss of skeletal muscle mass. Bioelectrical impedance analysis (BIA) is used for muscle mass evaluation. However, its high cost and limited accessibility are challenges. Ultrasound devices are widely used to evaluate vascular access in dialysis patients. The usefulness of ultrasound in measuring quadriceps and biceps brachii muscle thickness has been reported in healthy older adults and critical care settings. We aimed to evaluate its applicability in dialysis patients.

Methods: We assessed the handgrip strength and gait speed of 44 hemodialysis patients at our hospital before the dialysis session. After the same dialysis session, we measured the thickness of the biceps brachii and quadriceps muscles using the ultrasound device (SSA-640A Viamo, Canon Medical Systems, Japan). We evaluated the fat-free mass index (FFMI) using BIA (Inbody M20, InBody, South Korea). The cut-off value for reduced muscle mass was less than 17 kg/m² for men and less than 15 kg/m² for women.

Results: The average age was 69.9 ± 13.0 years old, with 28 males (63.6%) and a mean dialysis duration of 5.9 ± 5.4 years. Handgrip strength was 21.9 ± 10.5 kg in men and 13.6 ± 8.7 kg in women. FFMI was 15.5 ± 1.9 kg in men and 13.8 ± 1.5 kg in women. Reduced muscle mass was identified in 34 patients, and sarcopenia was identified in 30 patients. The mean biceps thickness was 21.1 ± 4.3 mm, and quadriceps thickness was 26.2 ± 8.4 mm. Patients with reduced handgrip strength had significantly lower biceps thickness (p <0.001) and quadriceps (p = 0.033). The diagnostic ability of ultrasound for sarcopenia was better for the biceps (AUC 0.735) than for the quadriceps (AUC 0.664).

Conclusion: Ultrasound-based muscle mass assessment of the biceps is valuable for diagnosing sarcopenia in hemodialysis patients.

Disclosure of Interest: None declared