PP282 - DIAGNOSTIC ACCURACY OF CALF CIRCUMFERENCE AS A MARKER OF MUSCLE MASS AND ITS IMPACT ON SARCOPENIA CLASSIFICATION

PP282

DIAGNOSTIC ACCURACY OF CALF CIRCUMFERENCE AS A MARKER OF MUSCLE MASS AND ITS IMPACT ON SARCOPENIA CLASSIFICATION

I. Damé Vogg^1,*, É. C. Ternus Ribeiro², M. D. Machado Vale^3,4, G. C. Souza^4,5

¹Graduate Program in Nutrition Science, University of Health Sciences of Porto Alegre, Porto alegre, Brazil, ²The George Institute for Global Health, Imperial College London, London, United Kingdom, ³Graduate Program in Cardiology and Cardiovascular Sciences, Federal University of Rio Grande do Sul, ⁴Hospital de Clínicas de Porto Alegre, ⁵Graduate Program in Food, Nutrition and Health, Medical School, Federal University of Rio Grande do Sul, Porto alegre, Brazil

Rationale: Sarcopenia assessment in heart failure(HF) is clinically relevant, as it is associated with worse outcomes. However, its identification remains challenging due to the limited feasibility of gold-standard methods in clinical practice. This study aimed to evaluate the diagnostic accuracy of calf circumference (CC) as a marker of muscle mass and its impact on sarcopenia classification in HF patients.

Methods: Cross-sectional study including individuals aged ≥18 years with confirmed with confirmed diagnosis of HF in outpatient follow-up at a university hospital in Brazil. Sarcopenia was identified according to the EWGSOP2: low appendicular skeletal muscle mass (ASMM), estimated using a specific equation based on bioelectrical impedance analysis data, and low muscle strength, assessed by handgrip strength test (HGS). CC was measured in the absence of edema using a non-elastic tape at the point of maximum circumference. The diagnostic accuracy of CC was evaluated using the ROC curve, and the AUC was calculated to determine its performance as a marker.

Results: 264 individuals were included, 67.4% male; mean±SD age: 56.5±12.7y; BMI: 28.7±4.91kg/m²; Left ventricular ejection fraction: 33.5±12.8%. In the assessment of the diagnostic accuracy of CC as an indicator of muscle mass, compared with ASMM (gold standard in this analysis),CC demonstrated excellent performance in both sexes (AUC=0.864;95%CI0.766–0.961;p<0.001 for women, and AUC=0.919;95%CI0.845–0.993; p<0.001 for men). Using a cutoff of 36cm, based on the ROC curve, CC showed sensitivity of approximately 89%(women) and 90%(men), along with a specificity of 84%(women) and 74%(men). The prevalence of sarcopenia according to EWGSOP2 criteria, it was 6.1% using ASMM and 9.1% using CC.

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Conclusion: CC proved to be a simple,accessible,and quite accurate method for assessing ASMM for sarcopenia screening in HF patients.

Disclosure of Interest: None declared