PD344 - NUTRITION RISK FACTORS IN PATIENTS WITH CHRONIC LIVER DISEASE: A NUTRITIONDAY ANALYSIS OF PREVALENCE AND OUTCOME IN THE COHORT 2016-2023

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PD344

NUTRITION RISK FACTORS IN PATIENTS WITH CHRONIC LIVER DISEASE: A NUTRITIONDAY ANALYSIS OF PREVALENCE AND OUTCOME IN THE COHORT 2016-2023

S. Tarantino1, M. HIESMAYR1,*, F. Trumshi1, E. Softic1, C. Schuh2, M. Pirlich 3

1Center for Medical Data Science, Institute of Medical Statistics, Medical University of Vienna, 2ITSC Medical University of Vienna, Vienna, Austria, 3Imperial Oak Outpatient Clinic, Berlin, Germany

 

Rationale: Comorbidities are important often chronic conditions that modify the disease trajectory of patients. Chronic liver disease (CLD) incidence and mortality is increasing while effect of individual nutrition risk factors on outcome is unclear. We compared the prevalence and association with outcome of nutrition related risk factors in patients with or without CLD in an exploratory analysis.

Methods: We determined in the adult nutritionDay cohort 2016-2023 the prevalence of the nutrition risk factors (low BMI, reduced eating before hospitalisation, unintentional weight loss and reduced eating at nutritionDay) in CLD patients (n: 3715), in patients with other comorbidities (n:48780) (COMORB) or no comorbidities (n:16136) (noCOMORB). Association with hospital mortality was determined with general linear models adjusted for age and sex (GLM STATA 19.0). P<0.001 was considered significant.

Results: The cohort 2016-23 includes 68631 adults from 3918 units in 66 countries with median age 65 [IQR 50;77], female 33807 (49.3%). CLD patients were 65a [54;74], female 39.7%. COMORB patients were older and noCOMORB younger. Low BMI was similar in CLD (7.8%), COMORB (7.8%) and noCOMORB (7.1%). Obesity in CLD (20%), COMORB (18%) and noCOMORB (14%). Unintentional weight loss in CLD (47%), COMORB (44%) and noCOMORB (30%). Reduced eating before hospital admission in CLD (42%), COMORB (34%) and noCOMORB (25%). Not eating the full meal on nutritionDay was reported in CLD (56%), COMORB (49%) and noCOMORB (45 %). Multivariable model are shown in figure. In all models CLD was associated with a higher hospital mortality OR 2.6-2.9, than COMORB 1.5-1.9 compared with noCOMORB (p<0.001)

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Conclusion: In CLD all nutrition risk factors are more prevalent than in COMORB and noCOMORB. All factors are associated with increasing mortality but in CLD high BMI is not pretective and mortality does not increase with age.

Disclosure of Interest: None declared