PD420 - ASSOCIATION OF GLIM-DEFINED MALNUTRITION AND HIGH NT-PROBNP WITH 90-DAY ADVERSE OUTCOMES IN ACUTE HEART FAILURE

PD420

ASSOCIATION OF GLIM-DEFINED MALNUTRITION AND HIGH NT-PROBNP WITH 90-DAY ADVERSE OUTCOMES IN ACUTE HEART FAILURE

A. Fujii^1,*, T. Saijo¹

¹Department of Nutrition Management, Osaka Rosai Hospital, Osaka, Japan

Rationale: Early risk stratification for prognosis after hospitalization is important in acute heart failure (AHF). GLIM Criteria for malnutrition, NT‑proBNP for heart failure severity; the utility of a combined indicators has not been adequately validated. This study evaluated whether a combined indicator of GLIM‑defined malnutrition and NT‑proBNP provides useful 90‑day prognostic stratification in AHF.

Methods: In this single‑center retrospective observational study (Nov 2024-Oct 2025), consecutive AHF admissions were analyzed. The primary endpoint was a composite outcome of all‑cause mortality or readmission within 90 days of admission. Malnutrition at admission was assessed by the GLIM Criteria. NT‑proBNP in the top tertile was defined as high (>8,000 pg/mL). Patients were classified into 4 groups by combining GLIM status and NT‑proBNP level: Group [GLIM-malnutrition/NT-proBNP]; Group1[(-)/Low], Group2[(+)/Low], Group3[(-)/High)], Group4[(+)/High)]. Associations with prognosis were evaluated using Cox proportional hazards models adjusted for age, sex, systolic blood pressure, serum sodium, and eGFR.

Results: Among 266 patients, 54 reached the composite outcome. GLIM‑defined malnutrition alone was not significantly with the composite outcome (HR 1.65, 95% CI 0.89-3.04), nor was high NT-proBNP alone (HR 1.70, 95% CI 0.96-2.99). Using Group 1 as reference, HRs were Group 2 1.22 (95% CI 0.49–3.04), Group 3 1.44 (95% CI 0.74–2.80), and Group 4 3.02 (95% CI 1.35–6.76). Group 4 showed significantly higher risk. Kaplan–Meier analysis also demonstrated significant differences among the 4 groups (log‑rank p = 0.02). The 4‑group model had the highest discrimination (C‑index of 0.713).

Conclusion: In patients with AHF, a 4‑group classification combining GLIM‑defined malnutrition and high NT‑proBNP may identify patients at high risk of adverse outcomes within 90 days of admission.

Disclosure of Interest: None declared