Sep 5, 2026
2:00 PM12:00 PM
ePoster display
PD324 - CHRONONUTRITION AND CHRONOTYPE IN METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE: A CASE–CONTROL PILOT STUDY
PD324
CHRONONUTRITION AND CHRONOTYPE IN METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE: A CASE–CONTROL PILOT STUDY
T. A. Alaidarous1, M. H. Alhussain1, M. M. A. Abulmeaty2,*, K. Alswat3, F. Abaalkhail4,5, W. K. Al-Hamoudi3,6, B. Al-Judaibi6, S. A. Alessy7,8, S. A. Alghamdi6, L. Amer6,9, S. A. Alqahtani6,8,10
1Food Sciences and Nutrition, 2Community Health Department , 3Liver Disease Research Centre, King Saud University, 4Medicine, Alfaisal University, 5Department of Medicine, Section of Gastroenterology, 6Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, 7Public Health Department, Saudi Electronic University, 8Liver, Digestive, and Lifestyle Health Research , 9Cell transplant &Stem Cell Unit, Kidney & Pancreas Health department, King Faisal Specialist Hospital and Research Center, Riyadh , Saudi Arabia, 10Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, United States
Rationale: Disruptions in chrononutrition and chronotype have been linked to metabolic dysregulation and may contribute to metabolic dysfunction-associated steatotic liver disease (MASLD) risk.1 This study aimed to examine the differences in chrononutrition behaviors and chronotype between patients with MASLD and controls.
Methods: This pilot case-control study included 40 participants (20 diagnosed with MASLD and 20 controls), aged 18 to 65 years, who were recruited from two tertiary centers in Riyadh. Demographic and anthropometric data were collected. Chrononutrition behaviors and chronotype were assessed using a structured questionnaire and the Morningness–Eveningness Questionnaire, respectively.
Results: Breakfast-related chrononutrition behaviors differed significantly between groups. Patients with MASLD had more irregular meal routines than controls (80.0% vs 20.0%; p < 0.001). Early breakfast timing (6:00–9:00 am) was more common among controls (73.7% vs 26.3%), whereas delayed timing (afternoon) was more frequent among participants with MASLD (70.0% vs 30.0%; p=0.027). However, the chronotype score did not differ significantly between groups (15.45±4.30 vs 14.85±4.53; p=0.670), nor did it differ significantly across chronotype categories. Body weight, BMI, fat mass, fat-free mass, and total body water were significantly greater in participants with MASLD than in the control group (all p < 0.05).
Conclusion: Disrupted breakfast timing and irregular chrononutrition behaviors may be linked to MASLD, whereas chronotype is not. Interventions that improve meal timing regularity may be a potential approach for MASLD management and metabolic health, warranting further investigation.
References: 1. Lee, H., & Rhee, S. Y. (2024). Association between dietary circadian rhythms and metabolic dysfunction-associated steatotic liver disease risk. Life Cycle, 4.
Disclosure of Interest: None declared