PD569 - DOES BODY MASS INDEX CORRELATE WITH SYSTEMIC INFLAMMATORY INDICES IN OBESITY? A SUBGROUP ANALYSIS OF THE NATIONWIDE OBREDI-TR COHORT

PD569

DOES BODY MASS INDEX CORRELATE WITH SYSTEMIC INFLAMMATORY INDICES IN OBESITY? A SUBGROUP ANALYSIS OF THE NATIONWIDE OBREDI-TR COHORT

K. Issever^1,*, A. Oral², A. C. Genç³, I. Solmaz⁴, N. Koca⁵, U. S. Topaloğlu⁶, I. Demir⁷, A. Dündar⁸, A. Kırık⁹, Ö. Kama Başçı⁹, H. Şen⁹, E. Binnetoğlu¹⁰, N. Okuroğlu¹¹, A. Aydın¹², Z. I. Kaya¹³, H. Yıldız¹⁴, A. Acet¹⁵, G. Tazegül¹⁶, H. Sözel¹⁷, O. Özüdoğru¹⁸, S. Yaylacı¹⁹, U. B. Korkmaz²⁰, N. Düzen Oflas²¹, C. Küçük²², K. Konur²³, T. Ayaz²⁴, A. Işıklar²⁵, E. Araç²⁶, H. E. Sümbül²⁷, H. A. Öztürk²⁷, A. B. Gövez²⁷, Y. U. Durmuş²⁷, A. Önmez²⁸, S. Ocak Serin²⁹, N. Yalçın⁵, A. Ertınmaz⁵, A. T. Güven³⁰, M. Kök³¹, Y. Şahintürk³¹, S. Uyar³¹

¹Internal Medicine, Giresun University Medical Faculty, Giresun, ²Biruni University Medical Faculty, ³Ahmed Cihad Genc Private Clinic, Istanbul, ⁴Gazi Yasargil Education Research Hospital, Diyarbakır, ⁵Health Sciences University Bursa Health Application and Research Center, Bursa, ⁶Kayseri City Hospital, Kayseri, ⁷Bozyaka Education Research Hospital, İzmir, ⁸Mardin Savur Prof. Dr. Aziz Sancar State Hospital, Mardin, ⁹Balıkesir University Medical Faculty, Balıkesir, ¹⁰Çorlu Vatan Hospital, Tekirdağ, ¹¹Fatih Sultan Mehmed Education Research Hospital, ¹²Medipol University Medical Faculty, Istanbul, ¹³Health Sciences University Eskisehir Health Application and Research Center, Eskişehir, ¹⁴Gaziantep University Medical Faculty, Gaziantep, ¹⁵Kutahya Health Sciences University, Kütahya, ¹⁶Marmara University Medical Faculty, Istanbul, ¹⁷Akdeniz University Medical faculty, Antalya, ¹⁸Erzincan Binali Yildirim University, Erzincan, ¹⁹Sakarya University Medical Faculty, Sakarya, ²⁰Izmir Katip Celebi Education Research Hospital, İzmir, ²¹Van Yuzuncu Yil University, Van, ²²Biruni University Medical Faulty, Istanbul, ²³Recep Tayyip Erdogan University Medical Faculty, Rize , ²⁴Bakircay University Cigli Education Research Hospital, İzmir, ²⁵Acibadem Atasehir Hospital, Istanbul, ²⁶Dicle University Medical Faculty, Diyarbakır, ²⁷Health Sciences University Adana Health Application and Research Center, Adana City Hospital, Adana , ²⁸Faculty of Medicine, Duzce University, Düzce, ²⁹Umraniye Education Research Hospital, Istanbul, ³⁰Başkent Universty Medical Faculty, Ankara, ³¹Antalya Education Research Hospital, Antalya, Türkiye

Rationale: Overnutrition drives chronic metabolic inflammation. However, the association between obesity classes, as defined by body mass index (BMI), and inflammation remains debated. We investigated whether Class III obesity linearly exacerbates novel inflammatory indices compared to Class I-II obesity using the multicenter OBREDI-TR cohort.

Methods: This multicenter retrospective analysis included 6,499 of 10,121 adults for whom laboratory data were available from 28 centers. Patients were grouped by BMI: Class I-II (30.0–39.9 kg/m², n=4,555) and Class III (≥40.0 kg/m², n=1,944). We compared anthropometrics, comorbidities, plasma biochemical parameters, and complete blood count-derived indices: neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI).

Results: Class III patients were significantly younger (42.7±13.2 vs. 44.7±14.0 years, p<0.001) with more females (80.6% vs. 68.4%, p<0.001). Despite higher BMI (44.9±4.6 vs. 34.1±2.9 kg/m², p<0.001) and waist circumference (122.4±13.9 vs. 107.5±11.5 cm, p<0.001) in Class III, inflammatory indices showed no significant differences. Surprisingly, hypertension prevalence was lower in the Class III obesity group (49.0% vs. 52.7%, p=0.006), likely due to the female predominance

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Conclusion: Progressing from Class I-II to Class III obesity does not linearly exacerbate systemic inflammation. This potential "ceiling effect" aligns with literature indicating that visceral adiposity and specific phenotypes—such as metabolically healthy versus metabolically unhealthy obesity—are more critical determinants of inflammatory and metabolic burden than total BMI alone. Nutritional therapies should prioritize metabolic profiling over simple BMI categorization.

Disclosure of Interest: None declared