PD376 - MEDITERRANEAN DIET BASED LIFESTYLE INTERVENTION IN MASLD PATIENTS

PD376

MEDITERRANEAN DIET BASED LIFESTYLE INTERVENTION IN MASLD PATIENTS

I. Matias^1,*, M. D. M. d’Orey¹, S. Policarpo², S. Carvalhana³, H. Cortez-Pinto⁴, M. Carvalho³, J. Estrabocha¹, R. Fernandes³, F. Capinha³, A. Neves³ on behalf of The GRIPonMASH project is supported by the Innovative Health Initiative Joint Undertaking (IHI JU) under grant agreement No 101132946. The JU receives support from the European Union’s Horizon Europe research and innovation programme and COCIR, EFPIA, Eur

¹Clinical Research Centre, AIDFM, ²Nutrition Laboratory, Faculty of Medicine, ³Gastroenterology Service, ULS Santa Maria, ⁴Clínica Universitária de Gastroenterologia, Faculty of Medicine, Lisboa, Portugal

Rationale: Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) is diagnosed in the presence of hepatic steatosis and a cardiometabolic risk factor. Early diagnosis/lifestyle intervention (LI), including the Mediterranean Diet (MD), is crucial to prevent fibrosis progression. This study aims to characterise a LI in patients with moderate fibrosis

Methods: Demographic, clinical (HOMA-IR, hepatic elastography -Fibroscan®- CAP for steatosis, LSM for stiffness) and nutritional (BMI, waist circumference-WC, neck circumference-NC, dietary intake) data were collected. Individuals with moderate fibrosis received a 3-month intervention based on the MD. The Healthy Eating Index (HEI) was calculated from the Food Frequency Questionnaire

Results: From 35 participants, 23 with moderate fibrosis, consented to undergo a LI and were included, 69.6% male, mean age 55.5. At baseline: 73.8% were obese; 56.5% had a NC above the cut-off; 73.9% had a WC above the cut-off; 82.6% had HOMA-IR predictive of insulin resistance (IR); 4.3% had poor and 95.7% had moderate dietary quality. After 3 months 78.3%  were obese; 21.7% had an NC above the cut-off; and 56.5% presented a WC above the cut-off. After the intervention a statistically significant difference was observed with mean fibrosis value decreasing from 10.9 kPa to 7.8 kPa (p<0.01); mean BMI decreasing from 34.6kg/m2 to 33.6kg/m2 (p=0.007); mean NC decreasing from 43.1cm to 40.0cm (p=0,009); mean WC decreasing from 110.2cm to 109.1cm (p=0,036); and mean weight loss of 3.3%. The only significant association found was HOMA-IR and NC (p=0.024) with 68.4% of patients with elevated NC also presenting HOMA-IR predictive of IR

Conclusion: Early LI in this group of patients, who present poor/moderate dietary quality, demonstrates potential to reduce fibrosis and mean BMI, WC and NC. NC should be included in the nutritional assessment of patients with metabolic conditions since it appears to be related with IR

Disclosure of Interest: None declared