LB095 - EFFECTIVENESS OF WEIGHT LOSS WITH DIFFERENT TIMING OF INULIN ADMINISTRATION: AN OPEN-LABEL RANDOMIZED CONTROLLED TRIAL

LB095

EFFECTIVENESS OF WEIGHT LOSS WITH DIFFERENT TIMING OF INULIN ADMINISTRATION:

AN OPEN-LABEL RANDOMIZED CONTROLLED TRIAL

 

T. Sitthipolkul^1,*, B. Tangjaturonrasme¹

¹Clinical Nutrition, Phramongkutklao Hospital, Bangkok, Thailand

 

Rationale: Inulin has been extensively studied for its potential health benefits, particularly its role in weight management. The World Health Organization (WHO) recommends that individuals consume at least 25 grams of dietary fiber daily to help control body weight while reducing fat and sugar intake. Previous research has shown that consuming inulin in doses of 15-30 grams per day for 8-16 weeks can lower the risk of diabetes by promoting weight loss. Soluble fibers, like inulin, increase feelings of fullness by delaying gastric emptying and triggering earlier satiety signals. However, pre-meal fiber intake seems to be more effective for enhancing satiety and controlling appetite. Despite these findings, no studies have examined the factors that influence the weight loss effectiveness of inulin. This study aims to compare the effectiveness of inulin intake before and after meals for weight loss in each group.

Methods: Seventy-five overweight and obese volunteers from the Nutrition and Home Infusion Care Clinic at Phramongkutklao Hospital were randomly selected using a computer randomization method and divided into three groups: a control group and two intervention groups (one group taking inulin before meals and the other after meals). The intervention groups received 26 grams of inulin per day for eight weeks. 

The primary outcome measured was body weight (BW) and body mass index (BMI) reduction after 8 weeks of intervention. The secondary outcomes included fasting blood glucose, HbA1c, LDL cholesterol, and body fat composition assessed through bioelectrical impedance analysis (BIA).

Results: The group taking inulin before meals experienced greater weight loss (-2.16 kg; 95% CI: -3.21 to -1.1) compared to the group taking inulin after meals (-1.61 kg; 95% CI: -2.45 to -0.75), although this difference was not statistically significant (p = 1.0). When compared to the control group, the inulin-before-meals group demonstrated significantly greater weight loss, a decreased BMI, and reduced hunger scores at the end of the 8th week (p < 0.05). Furthermore, both intervention groups showed a lower total calorie intake at the end of the 8th week compared to the control group (p < 0.002).

Conclusion: Inulin taken before meals at a dose of 26 grams per day demonstrated potential benefits for weight loss, appetite regulation, and reduced calorie intake compared to the control group.    

References:         1. Dayib, Miski; Larson, Jacob; Slavin, Joanne. Dietary Fibers Reduce Obesity-Related Disorders: Mechanisms of Action. Current Opinion in Clinical Nutrition and Metabolic Care 23(6): p 445-450, November 2020.

        2. Obesity and overweight. World Health Organization. (https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight, accessed 26 June 2023

        3. World Health Organization WHO updates guidelines on fats and carbohydrates

        4. Shoaib M, Shehzad A, Omar M, Rakha A, Raza H, Sharif HR, Shakeel A, Ansari A, Niazi S. Inulin: Properties, health benefits and food applications. Carbohydr Polym. 2016 Aug 20;147:444-454. 

 

Disclosure of Interest: None declared