P119 - HIGH CALORIES AND BELLY FAT INDEPENDENTLY DRIVE HEPATIC STEATOSIS IN LEAN INDIVIDUALS: A COMPLETE NUTRITIONAL ANALYSIS OF THE THIN FAT INDIAN

P119

HIGH CALORIES AND BELLY FAT INDEPENDENTLY DRIVE HEPATIC STEATOSIS IN LEAN INDIVIDUALS: A COMPLETE NUTRITIONAL ANALYSIS OF THE THIN FAT INDIAN

K. Bansal ¹, J. Benjamin ^2,*, P. B. Kapoor ², S. Khan ², C. Vashistha³, R. Maiwall ³, M. Sharma ³, S. Thappar ⁴, G. Kumar ⁵, A. Saraya ², Y. K. Joshi², S. K. Sarin³

¹Department of Clinical Nutrition , ²Clinical Nutrition , ³Hepatology, ⁴Radiology, ⁵Biostatistics , Institute of Liver and Biliary Sciences , New Delhi , India

Rationale: The risk factors for NAFLD in lean individuals are poorly described.

Aim: Identification of risk factors associated with hepatic steatosis in lean individuals.

Methods: In this observational study; all the implicated risk factors were studied in lean NAFLD (LN) and compared with lean healthy controls (HC), both at BMI <23Kg/m². Visceral adipose tissue area [VAT (cm²)], was assessed by CT and diet by 24 hours recall plus food frequency questionnaire.

Results: (84; 51%)HC and (79; 49%)LN were enrolled. Male gender, metabolic syndrome (MeS), calories, VAT, TG, uric acid, leptin and TNFα, intake of fullfat milk, cookies and sugar sweetened beverages(SSB) were significantly higher in LN than HC; HC vs. LN = age (yrs) 36.39± 9.20 vs. 37.14±10.2, p=0.565; males 29(34.5%) vs. 67(84.8%),p=0.001; Mes: 3(3.6%) vs. 26(32.9%), p=0.001; HbA1c 5.2±0.35 vs. 5.7±0.61,p=0.00; calories (Kcal/d) 1857±477 vs. 2480±626,p=0.001; fat(grams)=82.96±10 vs. 104.5±22,p=0.001; VAT(cm²):82.8±45 vs. 146±52, p=0.001; TG:102.35±71.1 vs. 156.3±73.4, p=0.00; Uric acid(mg/dl): 4.4±1.1 vs. 6.2±1.5, p=0.001; leptin(pg/ml): 856.8(203-3229) vs. 1000(60-5890); p=0.029; TNFα: 0.42(0.10-17.7) vs. 1.08(0.10-515),p=0.02. But physical activity(MET min/wk): 594(0-7722) vs. 693(0-4752),p=0.797; PNPLA3 gene (GG+CG):34(69.4%) vs. 41 (63.1%),p=0.482; and adiponectin:55.6(10.39-96.8) vs. 60.4(10.05-93), p=0.34 were comparable. In stepwise logistic regression analysis, VAT [OR (95%CI):1.018(1.004-1.031); p=0.00], total calories [1.002(1.001-1.003), p=0.00] and uric acid [2.34 (1.26-4.34),p=0.007] were found to be independent predictors of hepatic steatosis in lean individuals. 

Conclusion: Higher intake of added sugars as cookies, SSB along with fullfat milk contribute to greater calories, uric acid and VAT, that increase the risk of hepatic steatosis in lean individuals. 

Disclosure of Interest: None declared