PD528 - THE RELATIONSHIP BETWEEN PHASE ANGLE AND DISEASE ACTIVITY IN IBD PATIENTS RECEIVING BIOLOGICAL THERAPY

PD528

THE RELATIONSHIP BETWEEN PHASE ANGLE AND DISEASE ACTIVITY IN IBD PATIENTS RECEIVING BIOLOGICAL THERAPY

D. Demeter^1,*, D. Tarján¹, E. Fürst¹, P. Hegyi¹, P. A. Golovics¹

¹Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary

Rationale: Recent studies show that the phase angle (PhA) measured with a bioimpedance analyzer may be related to the patient's frailty, partly independent of the disease and current condition(1). 

Methods: We examined inflammatory bowel disease (IBD) patients undergoing biological therapy and compared the PhA with disease activity scores: in Crohn's disease (CD), with the Crohn's Disease Activity Index (CDAI), and in ulcerative colitis (UC), with the Mayo score.

Results: Of the 33 patients, 24 had CD, and 9 had UC. In UC, the Mayo score showed no correlation with the PhA.

In CD, we identified five patients with exceptionally low PhA. The lowest PhA was 4.4; the patient was on steroids. Her body composition had low muscle mass with high body fat. A patient with a PhA of 4.6 had not received steroids and had a history of surgery; her body composition was ideal. Two patients had a PhA of 4.7: one had been on steroid, had an ideal skeletal muscle mass, but reduced body fat percentage; another did not receive steroid treatment, had undergone one surgery, normal muscle mass, and increased body fat percentage. The fifth patient, with a PhA of 4.9, did not receive steroids at the time of measurement, had slightly reduced muscle mass and increased body fat percentage.

Conclusion: No clear correlation between disease activity and PhA was demonstrated in the present patient material. One possible explanation is that the general condition of the examined patients had not deteriorated enough to significantly decrease in PhA. On the other hand, it cannot be ruled out that, in IBD, disease activity alone is not the sole determining factor in the development of the PhA.

References:         1. Wilhelm-Leen ER, et al., Frailty and Mortality in Older Adults. J Gen Intern Med. 2014 Jan;29(1):147–54. 

Disclosure of Interest: None declared