LB048 - THE RELATIONSHIP OF MAGNESIUM LEVELS WITH NUTRITIONAL AND CLINICAL OUTCOMES IN BILIARY TRACT DISEASES

LB048

THE RELATIONSHIP OF MAGNESIUM LEVELS WITH NUTRITIONAL AND CLINICAL OUTCOMES IN BILIARY TRACT DISEASES

H. Aslan Sirakaya^1,*, H. Sipahioglu², A. Cetinkaya¹

¹Department of Internal Medicine, ²Department of İntensive Care Unit, Kayseri City Hospital, Kayseri, Türkiye

Rationale: Magnesium is a critical mineral for nutritional status and inflammatory response. Choledochal and intrahepatic biliary tract diseases (choledocholithiasis, cholangitis, obstruction) can lead to hypomagnesemia due to malabsorption and liver dysfunction. This study aims to investigate the relationship between magnesium levels and nutritional parameter, inflammatory markers and clinical outcomes in intensive care unit (ICU) patients with biliary tract disease.

Methods: In a retrospective cohort study, 123 ICU patients with biliary tract disease were evaluated. Magnesium levels (<1.7 mg/dL hypomagnesemia, 1.7-2.3 mg/dL normal) were measured. Nutritional (prealbumin, albumin), inflammatory (sedimentation rate, CRP) and clinical outcomes (7/28-day mortality, length of ICU stay) were analyzed. Control variables: age, gender, APACHE II score, endoscopy pathology (choledocholithiasis, cholangitis). Spearman correlation and logistic regression were used.

Results: The prevalence of hypomagnesemia was 44.7%. The rate of hypomagnesemia was higher in patients with choledocholithiasis (54.4%) compared to malignant obstruction (29.2%) (p=0.03). Magnesium was positively correlated with prealbumin (r=0.537, p<0.001) and albumin (r=0.331, p<0.001). Hypomagnesemia was associated with elevated sediment (r=-0.428, p<0.001) and CRP (r=-0.526, p<0.001). Hypomagnesemia was associated with a 7-day mortality risk (OR: 2.2, p=0.012) and prolonged ICU stay (p=0.040). Vitamin D deficiency increased hypomagnesemia (p=0.031).

Conclusion: In biliary tract diseases, hypomagnesemia is associated with malabsorption and inflammatory response; more common in choledocholithiasis. It is associated with poor nutritional status, high sedimentation rate and unfavorable clinical outcomes. Magnesium monitoring and replacement in the ICU may provide clinical benefit, especially in high-risk groups such as choledocholithiasis. In the future, the effects of magnesium therapy should be prospectively investigated.

Disclosure of Interest: None declared