PD947 - CHOLELITHIASIS IN PEDIATRIC PATIENTS RECEIVING LONG-TERM PARENTERAL NUTRITION

PD947

CHOLELITHIASIS IN PEDIATRIC PATIENTS RECEIVING LONG-TERM PARENTERAL NUTRITION

P. Świec^1,*, M. Danko¹, K. Popińska¹, K. Wiśniewska¹, D. Żmudzka¹, J. Żydak¹

¹Department of Pediatrics, Nutrition and Metabolic Disorders, Children's Memorial Health Institute, Warsaw, Poland

Rationale: Cholelithiasis is one of the known complications in patients requiring parenteral nutrition (PN).

Methods: We present a retrospective analysis of the incidence of cholelithiasis in 159 Polish pediatric patients in a Home Parenteral Nutrition Program (HPN) conducted at the Department of Pediatrics, Nutrition and Metabolic Disorders in the Children's Memorial Health Institute in 2025. To examine the association between cholelithiasis and the underlying cause of intestinal failure requiring parenteral nutrition (PN), we applied the chi-square (χ²) test of independence, setting the significance threshold at p < 0.05.

Results: Among these 159 patients requiring PN, 29 had cholelithiasis and 2 had choledocholithiasis, corresponding to an overall prevalence of 19.5%. 

Most patients with cholelithiasis in our cohort had a history of necrotizing enterocolitis (NEC) or midgut volvulus. No statistically significant association was found between cholelithiasis and NEC (p>0.5), while a statistically significant association was found between cholelithiasis and midgut volvulus (p=0.01).

Approximately one third of the cohort underwent cholecystectomy, with a median age of 5 years and 8 months at the time of surgery. Among them 90% had short bowel syndrome (SBS) and 10% had intestinal motility disorders. 

All affected patients were treated with ursodeoxycholic acid (UDCA) and underwent regular ultrasonographic follow-up. 

Conclusion: Cholelithiasis in long-term HPN patients is relatively common and, although rarely symptomatic, warrants regular monitoring.

Disclosure of Interest: None declared