O004 - PRE-TREATMENT IMPACT OF BODY COMPOSITION AND MUSCLE STRENGTH ON SURVIVAL IN WOMEN WITH BREAST CANCER

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O004

PRE-TREATMENT IMPACT OF BODY COMPOSITION AND MUSCLE STRENGTH ON SURVIVAL IN WOMEN WITH BREAST CANCER

L. Cintra Vaz Ribeiro1,*, L. Vaz Gonçalves2, L. Ribeiro Soares3, R. Freitas Júnior3, K. Anusca Martins1, M. C. Gonzalez 4, C. M. Prado 5, J. F. Mota1, J. C. Marques Godinho Mota1

1Nutrition Department, Federal University of Goias, Goiania, Brazil, 2School of Public Health, The University of Queensland, Brisbane, Australia, 3Centro Avançado de Diagnóstico da Mama, Federal University of Goias, Goiania, 4Postgraduate Program in Nutrition and Food, Federal University of Pelotas, Pelotas, Brazil, 5Department of Agricultural, Food & Nutritional Science, University of Alberta, Alberta, Canada

 

Rationale: Obesity, low muscle mass, and strength have been associated with poorer treatment response and reduced overall and disease-specific survival in patients with breast cancer. We aimed to investigate the prognostic impact of these conditions at the time of diagnosis in women with breast cancer.

Methods: We conducted a prospective cohort including 77 women. Anthropometric assessments included body mass index (BMI) and waist circumference (WC). Body composition was assessed using dual-energy x-ray absorptiometry (DXA) and muscle strength using handgrip strength (HGS). The load-capacity model (LCM) was calculated using the  fat mass to fat-free mass ratio. 

Results: After a median follow-up of 8.2 years (range 7.1-9.2 years) for overall survival, 51.9% of the women died. Of those, 69.2% died due to breast cancer. No differences between survivors and deceased participants regarding age, fat mass, or gait speed were found. However, women who died had significantly higher BMI (28.3±6.6 vs. 25.4±4.6 kg/m2; p=0.02), WC (92.1±31.5 vs. 85.3±17.7 cm; p=0.01), lower appendicular lean mass (ALM)/body weight (22.58±3.35 vs. 24.02±2.78, p=0.01), and HGS (20.7±5.3 vs. 22.5±3.9 kg, p=0.04). LCM tended to be higher in the women who died (0.751±0.247 vs. 0.680 ±0.183, p=0.08). Low HGS and obesity were significantly more prevalent in patients who died (22.5 vs. 2.7%, p=0.01; and 30.0 vs. 10.0%, p=0.03, respectively).

Conclusion: Low handgrip strength, higher BMI, and WC at diagnosis of breast cancer were significantly associated in the group of those who died during the follow-up period. These findings suggest that muscle strength  and obesity may serve as relevant prognostic markers in women with breast cancer.

Disclosure of Interest: L. Cintra Vaz Ribeiro: None declared, L. Vaz Gonçalves: None declared, L. Ribeiro Soares: None declared, R. Freitas Júnior: None declared, K. Anusca Martins: None declared, M. C. Gonzalez Consultant for: Nestle Health Science Brazil, Speakers Bureau of: Nutricia and Abbott , C. M. Prado Consultant for: Abbott Nutrition, Nutricia, Novo Nordisk, Other: Speaker engagement: Abbott Nutrition, Nutricia, Nestle Health, Novo Nordisk , J. Mota: None declared, J. Marques Godinho Mota: None declared