PD790 - ABNORMAL EXTRACELLULAR MASS AND POORER SURVIVAL IN WOMEN WITH BREAST CANCER

PD790

ABNORMAL EXTRACELLULAR MASS AND POORER SURVIVAL IN WOMEN WITH BREAST CANCER

F. N. da Costa¹, G. D. A. Barbosa², R. M. Uchoa², J. P. Costa-Pereira³, A. P. T. Fayh^4,*, S. M. M. L. Verde²

¹Graduate Program in Public Health, ²Graduate Program in Nutrition and Health, State University of Ceará, Fortaleza, ³Graduate Program in Nutrition, Federal University of Pernambuco , Pernambuco, ⁴Graduate Program in Nutrition Sciences (PPGNUT), Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil

Rationale: Changes in cellular integrity are associated with poorer survival in women with breast cancer, and electrical bioimpedance parameters have been proposed as indirect markers of this condition. This study evaluated the association between indicators of cellular integrity and survival in women with breast cancer. 

Methods: Longitudinal analytical study of 233 women (aged 19 years and older) with breast cancer treated at Brazilian cancer centers. Sociodemographic, clinical (staging and histopathological grade), anthropometric (weight, height, and body mass index—BMI), and electrical bioimpedance parameters (phase angle, extracellular mass—ECM, body cell mass—BCM, extracellular water—ECW, and intracellular water—ICW) were collected. The ECM/BCM ratio was calculated between these compartments. Survival was defined as time to death from the disease, with censoring at remission. Cox regression adjusted for histopathological grade (5%) was used.

Results: The study population had a mean age of 48.4 ± 10 years and a mean BMI of 29.3 ± 5.9 kg/m²; 59.4% were postmenopausal, 48.6% were at clinical stage III, and 64.3% had histopathological grade II. The rate of disease-related mortality was 6.4%. The extracellular-to-cellular mass ratio was 1.15, indicating expansion of the extracellular compartment and poorer cellular quality. In Cox regression, each 1-unit increase in ECM and ECW was associated with a higher risk of death ([HR=1.19; 95% CI: 1.02–1.39; p=0.026] and [HR=1.23; 95% CI: 1.01–1.50; p=0.035], respectively), whereas the phase angle, and ICW were not associated with the risk of death.

Conclusion: ECM and ECW were independently associated with mortality risk, highlighting their potential as prognostic markers in women with breast cancer.

Disclosure of Interest: None declared