PD325 - BIOELECTRICAL IMPEDANCE - DERIVED MUSCLE MASS CORRELATES STRONGER WITH CT-DERIVED MASS THAN UPPER ARM CIRCUMFERENCE IN POLYCYSTIC LIVER DISEASE

PD325

BIOELECTRICAL IMPEDANCE - DERIVED MUSCLE MASS CORRELATES STRONGER WITH CT-DERIVED MASS THAN UPPER ARM CIRCUMFERENCE IN POLYCYSTIC LIVER DISEASE

F. Seltsam¹, K. Bohlen¹, S. Arndt¹, J. Leker¹, B. Hild^1,*, J. Haubold², J. Best¹, M. Krawczyk¹, H. H.-J. Schmidt¹

¹Department of Gastroenterology, Hepatology and Transplant Medicine, ²Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany

Rationale: Polycystic liver disease (PLD) is a rare ciliopathy characterized by a progressive growth of hepatic cysts that may cause gastrointestinal compression, reduced appetite, leading to malnutrition and sarcopenia. European clinical practice guidelines on the management of cystic liver disease¹ and german criteria for liver transplantation in PLD include upper arm circumference (UAC) independent of body size. In the current study we compare bioelectrical impedance analysis (BIA) and UAC for muscle assessment, as tools to detect malnutrition in patients with PLD. 

Methods: We analyzed patients with PLD who underwent BIA, UAC, and CT-derived muscular mass (CT-SMM) at our center from 2024 to 2026. CT-SMM was used as reference method. Univariate linear regression as wells as Akaike Information Criterion (AIC)-based model comparison were used to compare used tools. 

Results: Fifty patients with PLD were included (30 females, age range 37 – 73 years). The mean interval between BIA and CT was 2.9 ± 2.2 months. Univariate linear regression revealed a significant association between BIA-SMM and CT-SMM (p = 0.046, R² = 0.08) but no significant association between UAC and CT-SMM (p = 0.157; R² = 0.04). AIC was lowest for the BIA-SMM model (70.4) compared to the UAC model (72.5). 

Conclusion: BIA-SMM, compared to UAC, demonstrated a significant association with CT-SMM, despite UAC being the recommended method for assessing malnutrition in PLD. While UAC may be influenced by fat, dialysis access, fluid status, and measurement variability, BIA-SMM appears to more directly reflect muscle mass. Therefore, criteria for liver transplantation in PLD need a new assessment. 

References: European Association for the Study of the Liver, Drenth J, Barten T, Hartog H, Nevens F, Taubert R, Torra Balcells R, Vilgrain V, Böttler T. J Hepatol 2022;77:1083–1108.

Disclosure of Interest: F. Seltsam Speakers Bureau of: Gilead Sciences, Chiesie GmbH, and Mirum Pharmaceuticals., Other: Travel funding: Ipsen S.A., Gilead Sciences, and Amgen Inc, K. Bohlen: None declared, S. Arndt: None declared, J. Leker: None declared, B. Hild: None declared, J. Haubold: None declared, J. Best: None declared, M. Krawczyk: None declared, H. Schmidt: None declared