P953 - EFFECT OF A NUTRITIONAL SUPPORT PROGRAM INCLUDING A DIABETES-SPECIFIC NUTRITIONAL FORMULA WITH Β‐HYDROXY Β‐METHYLBUTYRATE (HMB) ON NUTRITIONAL STATUS AND MUSCLE HEALTH IN MALNOURISHED PATIENTS WITH DIABETES IN A REAL-LIFE SETTING: PRELIMINARY RESULTS

P953

EFFECT OF A NUTRITIONAL SUPPORT PROGRAM INCLUDING A DIABETES-SPECIFIC NUTRITIONAL FORMULA WITH Β‐HYDROXY Β‐METHYLBUTYRATE (HMB) ON NUTRITIONAL STATUS AND MUSCLE HEALTH IN MALNOURISHED PATIENTS WITH DIABETES IN A REAL-LIFE SETTING: PRELIMINARY RESULTS

J. M. Garcia-Almeida^1,*, J. M. Guardia-Baena², S. Palma Milla ORCID: 0000-0002-0187-1495^3,4,5, M. J. Martínez-Ramírez, MD, PhD⁶, M. J. Molina-Puerta⁷, J. F. Merino-Torres, MD, PhD^8,9, M. Civera-Andrés^10,11, P. P. Garcia-Luna¹², G. Olveira-Fuster^13,14,15, J. I. Botella-Carretero¹⁶, I. Rebollo-Pérez ORCID. 0000-0002-2261-8210¹⁷, F. J. Vílchez-Lopez^18,19, M. Maíz-Jiménez²⁰, Y. García-Delgado²¹, L. A. Calles-Romero²², P. Suryawanshi²³, M. Camprubi-Robles²⁴, G. Guzman Rolo²⁵, P. Matía-Martín^26,27 on behalf of Research group GLADIATOR study

¹Endocrinology and Nutrition Service, Hospital Universitario Virgen de la Victoria, Málaga, ²Endocrinology and Nutrition Service, Hospital Universitario Virgen de las Nieves, Granada, ³Coordinator of the Clinical Nutrition and Dietetics Unit. Endocrinology and Nutrition Service, Hospital Universitario La Paz, ⁴Associate Professor of Health Sciences, Department of Medicine, Universidad Autónoma de Madrid, ⁵Instituto de Investigación Sanitaria IdiPAZ, Madrid, ⁶Head of Service and Director of UGC Endocrinology and Nutrition, Hospital Universitario de Jaén, Jaen, ⁷Endocrinology and Nutrition Service, Hospital Universitario Reina Sofia, Córdoba, ⁸Endocrinology and Nutrition Service, Hospital Universitario Politécnico La Fe, ⁹Professor of Medicine, Universidad de Valencia, ¹⁰Endocrinology and Nutrition Service, Hospital Clínico Universitario de Valencia, ¹¹INCLIVA Instituto de investigación Sanitaria, Valencia, ¹²Endocrinology and Nutrition Clinical Management Unit, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, ¹³Universidad de Malaga, Instituto de Investigación Biomedica de Málaga (IBIMA)-Bionand Platform, ¹⁴Endocrinology and Nutrition Department, Hospital Regional Universitario de Málaga, Málaga, ¹⁵CIBER of Diabetes and Associated Metabolic Diseases, Instituto de salud Carlos III, ¹⁶Endocrinology and Nutrition Department, Hospital Universitario Ramón y Cajal, Madrid, ¹⁷Endocrinology and Nutrition Unit, Hospital Universitario Juan Ramón Jimenez de Huelva, Huelva, ¹⁸- Endocrinology and Nutrition Department, Hospital Universitario Puerta del Mar, ¹⁹Instituto de Investigación e Innovación Biomédica de Cádiz, Cádiz, ²⁰Endocrinology and Nutrition Department, Hospital Universitario 12 de Octubre, Madrid, ²¹Endocrinology and Nutrition Department, Complejo Hospitalario Universitario Insular-Materno Infantil, Gran Canaria, ²²Endocrinology and Nutrition Department, Hospital Universitario Basurto, Bilbao, Spain, ²³Statistical Services, Cognizant Technologies Solution Pvt. Ltd., Mumbai, India, ²⁴Research and Development, Abbott Laboratories, Granada, ²⁵Medical Department, Abbott Laboratories, ²⁶Endocrinology, Metabolism and Nutrition Department, Hospital Clínico San Carlos, ²⁷Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain

Rationale: Type 2 diabetes (T2DM) is considered a cause and consequence of sarcopenia, which can be exacerbated by malnutrition. This study assessed the impact of a nutritional support program including a diabetes-specific nutritional formula enriched with HMB (HP-DSNF+HMB) on metabolic and functional parameters in malnourished T2DM patients.

Methods: A multicenter real-world evidence study was conducted in patients receiving a program with dietary and exercise recommendations and 2 servings of a HP-DSNF+HMB daily for 3 months. The primary outcome was nutritional status, and secondary outcomes included diabetes-related parameters and muscle function. An interim analysis was done including evaluable patients with ≥70% of HP-DSNF+HMB intake. P-values ≤ 0.01 were considered significant for interim analysis.

Results: We included 63 patients (84% male), average age of 68 years. All patients were at high risk of malnutrition (per MUST) and 43.6% were severely malnourished (per SGA).  More than 50% patients significantly improved the nutritional status. Mean body weight, BMI and calf circumference increased. The changes were not statistically different, but they may be clinically relevant. HbA1c levels were maintained (6.49 vs 6.45%; p=0.7), and fasting blood glucose levels decreased (-13.7±6 mg/dl; p=0.026). Vitamin D serum levels increased (p<0.0001). There was an improvement in chair stand test (change of 1.6 s±0.4; p=0.0011). Compliance was 96%.

Conclusion: The preliminary results demonstrate that HP-DSNF+HMB use as part of a nutritional support program associates with improved nutritional status, maintained glycemic control, and enhanced muscle function in malnourished patients with T2DM in a real-world setting.

Disclosure of Interest: None declared