O074 - MUSCLE RADIODENSITY AND INTRAMUSCULAR ADIPOSE TISSUE AS INDEPENDENT PREDICTORS OF MORTALITY IN ESOPHAGOGASTRIC CANCER: A LONGITUDINAL STUDY
O074
MUSCLE RADIODENSITY AND INTRAMUSCULAR ADIPOSE TISSUE AS INDEPENDENT PREDICTORS OF MORTALITY IN ESOPHAGOGASTRIC CANCER: A LONGITUDINAL STUDY
E. Vieira Maroun1,*, M. Argente Pla1, A. Ramos 1, A. Cebrián Vazquez1, A. Micó García1, S. Martin Sanchis1, L. Cano Jiménez1, J. F. Merino Torres1
1Endocrinología y Nutrición, Hospital Universitario y Politécnico La Fe , Valencia, Spain
Rationale: Multiple morphofunctional parameters are used to assess nutritional and muscle status in cancer patients, but their relative prognostic value remains unclear. Identifying which parameter best predicts mortality is essential in esophagogastric cancer.
Methods: Longitudinal study including 85 patients with esophageal (65.9%) or gastric (35.1%) cancer. Baseline was defined as the first assessment in the Nutrition Unit. Body composition was evaluated at L3 by CT (FocusedON-BC®), bioelectrical impedance(NUTRILAB®), rectus femoris ultrasound, handgrip strength (JAMAR®), and SPPB. Statistical analyses included descriptive statistics, group comparisons, and Cox regression adjusted for age and tumor stage.
Results: Patients were 62.9±10.6 years old and 77.6% male; 75.3% had stage III–IV disease; 67.9% underwent surgery, 91.7% chemotherapy, and 25.0% radiotherapy. Twenty-one deaths (24.71%) were recorded. Among deceased patients, the mean time from baseline to death was 313 ± 245 days. In Cox analysis, muscle radiodensity was associated with lower mortality (HR=0.96; 95%CI 0.94–0.99; p=0.009), while intramuscular adipose tissue was associated with increased mortality (HR=1.12; 95%CI 1.03–1.21; p=0.007). Other body composition and functional parameters were not significant, although some showed trends, including the chair stand test (HR=1.04; 95%CI 1.00–1.08; p=0.067). At baseline, muscle radiodensity was higher in survivors than deceased (29.58±13.00 HU vs. 23.79±21.73 HU), while IMAT was lower (3.02±2.56cm2/m2 vs. 5.08±7.17cm2/m2), without statistical significance.
Conclusion: CT-derived muscle radiodensity and intramuscular adipose tissue were independently associated with mortality. These findings highlight the potential prognostic value of muscle quality. Larger studies may provide greater statistical robustness and help clarify the role of other parameters.
Disclosure of Interest: None declared