P857 - EXPLORING THE RELATIONSHIP BETWEEN DIETARY INTAKE AND GLUCOSE REGULATION IN OVERWEIGHT AND OBESE INDIVIDUALS USING CGM

P857

EXPLORING THE RELATIONSHIP BETWEEN DIETARY INTAKE AND GLUCOSE REGULATION IN OVERWEIGHT AND OBESE INDIVIDUALS USING CGM

G. Bilande^1,*, S. Ivanova ¹, M. Arisova¹, S. Skrebinska ¹, Z. Šmite¹, A. Fedulovs¹, J. Sokolovska¹

¹University of Latvia, Riga, Latvia

Rationale: Continuous glucose monitoring (CGM) is primarily used to identify glucose patterns in individuals with diabetes. In this study, CGM was utilized to investigate the associations between dietary intake, biochemical markers, and CGM-derived glucose metrics in individuals with overweight and obesity but without diabetes.

Methods: This cross-sectional study analysed data from Latvian residents participating in the PRAESIIDIUM study (ClinicalTrials.gov ID: NCT06195566). CGM data were collected over 14 days using the Libre ProIQ (Abbott) device from 60 participants. Inclusion criteria were adults with normal glucose metabolism (fasting glucose <5.6 mmol/L and HbA1c <5.7%) and a body mass index (BMI) of 25–34.9 kg/m². 

Results: Data from 60 participants (77% female, median age 35, BMI 28.5 kg/m², waist-to-hip ratio 0.85) were analyzed. Higher confectionery intake was weakly associated with increased TBR (rs = 0.304, p = 0.018), and consumption of sweets and soft drinks was linked to higher average glucose (rs = 0.253, p = 0.051). Greater intake of meat, offal (rs = 0.26, p = 0.044), and fish & seafood (rs = 0.252, p = 0.05) correlated with increased TITR. Elevated C-peptide levels were associated with lower TBR, higher TAR (rs = 0.341, p = 0.008), and average glucose (rs = 0.362, p = 0.004). Higher triglycerides significantly correlated with longer TAR and elevated glucose (rs = 0.483 and 0.426, p < 0.001).

Conclusion: Higher C-peptide and triglyceride levels were associated with poorer glucose regulation, while frequent intake of confectionery and sugary drinks correlated with glucose dysregulation. In contrast, regular consumption of meat, offal, and fish was linked to greater glycaemic stability.

Disclosure of Interest: None declared