PD711 - SEX-RELATED DIFFERENCES IN TUMOR SITE, MALNUTRITION SEVERITY AND SARCOPENIA IN CANCER PATIENTS WITH MALNUTRITION: ANYVIDA SUBANALYSIS

PD711

SEX-RELATED DIFFERENCES IN TUMOR SITE, MALNUTRITION SEVERITY AND SARCOPENIA IN CANCER PATIENTS WITH MALNUTRITION: ANYVIDA SUBANALYSIS

M. D. C. FERNANDEZ LOPEZ^1,*, B. De Leon Fuentes¹, E. Diego Perojo¹, H. Rendon Barragan², M. T. Yeregui Balda², B. Rodriguez Montalvan³, M. J. Chinchetru Ranedo³, S. Lanes Iglesias⁴, R. Fernandez Jimenez⁵, I. Gonzalo Montesinos⁶, J. M. Garcia-Almeida⁵ on behalf of Anyvida Group

¹Endocrinologia y Nutricion, Hospital Universitario Cruces, Bilbao, ²Nutricion, Hospital Universitario de Navarra, Pamplona, ³Endocrinologia y Nutricion, Hospital Universitario San Pedro, ⁴Endocrinologia y Nutricion, Hospital Universitario San Pedro, Logroño, ⁵Nutricion, Hospital Clinico Universitario Virgen de la Victoria, Malaga, ⁶Endocrinologia y Nutricion, Hospital Universitario de Fuenlabrada, Madrid, Spain

Rationale: Sex differences in body composition are well known, but their impact on malnutrition severity and sarcopenia in cancer remains unclear. We explored sex-related differences in tumor site, GLIM severity and confirmed sarcopenia.

Methods: Observational subanalysis of the ANYVIDA study including 517 cancer patients with GLIM-defined malnutrition (299 men, 218 women). Sex groups were compared for tumor variables, GLIM criteria and confirmed sarcopenia according to EWGSOP2 using chi-square tests.

Results: Histology was similar in both sexes, with carcinoma and adenocarcinoma predominating. Upper gastrointestinal and lung tumors were more frequent in men, whereas gynecological-urological and hematological tumors predominated in women. Advanced disease predominated in both groups, with a similar stage distribution.

All patients met GLIM criteria for malnutrition. Severe malnutrition was more frequent in women (24.2% vs 17.0%), with a significant association between sex and GLIM severity (χ²=3.91; p=0.048). This was not explained by greater weight loss, which was similar in both sexes, but by a higher frequency in women of severe criteria related to low BMI, marked muscle loss and chronic inflammatory burden. Confirmed sarcopenia was also more frequent in women than in men (27.3% vs 13.0%; χ²=14.3; p<0.001).

Conclusion: Female sex was associated with a higher prevalence of sarcopenia and a greater proportion of severe GLIM malnutrition, despite no clearly more advanced baseline tumor stage. These findings suggest greater nutritional and muscular vulnerability in women and support sex-sensitive morphofunctional and nutritional assessment in oncology.

References: Zohri R, Hahn L, et al. Nutritional gender-specific differences in head and neck cancer patients treated with (chemo)radiotherapy: results from a prospective trial. Cancers (Basel). 2024;16(23):4080.

Disclosure of Interest: None declared