PP029 - DEPRESSION IN CHRONIC INTESTINAL FAILURE : ASSOCIATIONS WITH DISEASE BURDEN IN PATIENTS RECEIVING HOME PARENTERAL NUTRITION

PP029

DEPRESSION IN CHRONIC INTESTINAL FAILURE : ASSOCIATIONS WITH DISEASE BURDEN IN PATIENTS RECEIVING HOME PARENTERAL NUTRITION

D. Palangasinghe^1,*, S. Tayyab¹, C. Ezeigwe², S. Brooks², E. Tesfaye², T. Tahir²

¹Gastroenterology, ²Liaison Psychiatry, University Hospital of Wales, Cardiff, United Kingdom

Rationale: Despite the known burden of home parenteral nutrition (HPN), the prevalence of depression and its links to HPN intensity and clinical burden in this population remain poorly understood.

Methods: A cross‑sectional study was conducted in HPN patients at a UK specialised IF centre. Depression was assessed using the Patient Health Questionnaire‑9 (PHQ‑9), with scores ≥10 indicating clinically significant depression. Emotional distress and anxiety were assesed using the Emotional Thermometer tool. Demographic data, aetiology, HPN duration, infusion frequency, daily PN energy and volume, proportion of energy delivered parenterally, recent catheter‑related complications and hospital admissions in the previous year were extracted from records. HPN dependence was defined as ≥75% of estimated energy delivered parenterally. Continuous variables were compared using Mann–Whitney U tests and categorical variables using Fisher’s exact test.

Results: Twenty‑five patients were included. Clinically significant depression was identified in 68% of patients and was associated with higher emotional distress scores (p<0.01). Median HPN duration was longer in patients with depression, although was not statistically significant. No significant differences were observed between the patients with and without depression in PN energy provision and volume, infusion nights, or HPN dependence. Depression was observed across all IF aetiologies. Recent hospital admissions and catheter‑related complications were numerically more frequent in patients with depression, although were not statistically significant.

Conclusion: Depression is highly prevalent among patients requiring HPN and associated with psychological distress. However, the findings are not explained by HPN intensity or disease burden alone. Routine depression screening and integrated mental health support should be considered.

Disclosure of Interest: None declared