PD067 - ASSOCIATION BETWEEN THE PROGNOSTIC NUTRITIONAL INDEX AND MORTALITY IN PATIENTS WITH HEART FAILURE

PD067

ASSOCIATION BETWEEN THE PROGNOSTIC NUTRITIONAL INDEX AND MORTALITY IN PATIENTS WITH HEART FAILURE

G. Benitez-Moya^1,2,*, D. González-Islas², A. Orea-Tejeda², J. Ruan-Díaz², E. Vargas-Corona², J. De la Borda-Paredes², L. Ramírez-Morales², D. Bonilla-Cuatepotzo², K. García-Díaz², V. Maldonado-Vargas², G. Cruz-Gijón², G. Rentería-Serralde², S. Alday-Ramirez², R. Sanchéz-Santillan², B. Valderrábano-Salas²

¹Facultad de Ciencias de la Nutrición y Alimentos, Universidad Autónoma de Ciencias y Artes de Chiapas, Tuxtla Gutiérrez, Chiapas, ²Unidad Clínica de Investigación Cardiopulmonar y Metabólica. Servicio de Cardiología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Ciudad de México, Mexico

Rationale: Heart failure (HF) is a syndrome resulting from structural or functional impairment, associated with changes in nutritional status and worse prognostic(1). The prognostic nutritional index (PNI) is a nutritional tool associated with cardiovascular events and mortality(2). Our objective was to evaluate the association between PNI and mortality in HF subjects.

Methods: A Cross-sectional study was conducted in patients older than 18 years with HF. Patients with hospitalization <3months were excluded. The PNI was calculated as: (10×serum albumin,g/dL)+(0,005×Total Lymphocyte Count,/mm³), with a cutoff point of <52. Group comparisons were using X² for qualitative variables and T-Student for quantitative variables. The risk of death was assessed using adjusted logistic regression.

Results: Of the 480 patients included, 13.95% non-survival. 57.92% were male, with a mean age of 67.20±25.25, 70.69% had HFpEF, 43.88% RHF, 59.5% systemic hypertension, and 43.63% diabetes. The non-survival group showed a low diabetes (28.79% vs 46%, p=0.009), albumin (3.73 vs 3.98, p=0.001), and more malnutrition (84.85 vs 63.64%, p=0.015) compared with survival group. Patients with a PNI score <52 had 4 fold increased risk of death (OR:4.08, 95% CI: 1.33 to 12.45, p=0.013) compared with a PNI score >52 adjusted for confounding variables.

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Conclusion: Malnutrition assessed by PNI is associated with a higher mortality risk in HF patients

References: 1.Heidenreich PA, et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(18):e895-e1032.

2.Zhang X, et al. Prognostic Nutritional Index (PNI) as a Predictor in Patients with Metabolic Syndrome and Heart Failure. Diabetes Metab Syndr Obes. 2023;16:2503-2514.

Disclosure of Interest: None declared