P277 - EFFECTIVENESS OF A MULTIMODAL NUTRITIONAL INTERVENTION IN CANCER PATIENTS WITH DISEASE-RELATED MALNUTRITION: A RETROSPECTIVE OBSERVATIONAL STUDY

P277

EFFECTIVENESS OF A MULTIMODAL NUTRITIONAL INTERVENTION IN CANCER PATIENTS WITH DISEASE-RELATED MALNUTRITION: A RETROSPECTIVE OBSERVATIONAL STUDY

A. J. Vidal Casariego^1,*, S. J. Cadahía Lema¹, G. J. Lugo Rodríguez¹, T. J. Martínez Ramonde¹

¹Unidad de Nutrición , Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain

Rationale: This study aimed to evaluate the effectiveness of a multimodal nutritional intervention in cancer patients diagnosed with disease-related malnutrition.

Methods: A retrospective observational study was conducted in adult patients with solid or hematologic malignancies referred to the Nutrition Unit of a tertiary hospital. Inclusion criteria were diagnosis of malnutrition based on GLIM criteria, completion of follow-up, and receipt of a structured multimodal intervention. This included: (1) individualized dietary counseling; (2) oral nutritional supplementation enriched with leucine and omega-3 fatty acids; (3) adapted physical exercise program; and (4) symptom management (e.g., anorexia, dysphagia, gastrointestinal symptoms). Body composition, functional, inflammatory, and QoL variables were assessed at baseline and follow-up.

Results: Twenty-five patients (60% male, mean age 67.2 years [SD 13.4]) were included. Main cancer types were gastrointestinal (40%) and head and neck (32%). Following intervention, significant improvements were observed in weight (57.64 [11.01] vs 60.34 [12.63] kg, p < 0.001), BMI (21.45 [3.11] vs 22.41 [3.51] kg/m², p < 0.001), phase angle (4.93 [0.75] vs 5.28 [0.85], p = 0.009), fat-free mass (16.91 [2.47] vs 17.83 [2.23] kg/m², p = 0.001), and appendicular skeletal muscle index (6.06 [1.08] vs 6.48 [0.99], p = 0.002). Platelet-to-lymphocyte ratio and systemic inflammation index significantly decreased (p = 0.033 and p = 0.036, respectively). QoL improved (EQ-5D VAS: 56.80 [20.30] vs 72.00 [17.32], p = 0.007), and ECOG functional status improved significantly (reduction in ECOG ≥2: 24% to 4%, p = 0.019).

Conclusion: A multimodal nutritional intervention significantly improved nutritional and functional parameters in malnourished cancer patients, supporting its integration into routine oncology care.

Disclosure of Interest: None declared