P734 - NEPHROPROTECTIVE EFFECT OF GINGER (ZINGIBER OFFICINALE) EXTRACT AGAINST PARACETAMOL-INDUCED KIDNEY DAMAGE IN MALE WISTAR RATS

P734

NEPHROPROTECTIVE EFFECT OF GINGER (ZINGIBER OFFICINALE) EXTRACT AGAINST PARACETAMOL-INDUCED KIDNEY DAMAGE IN MALE WISTAR RATS

A. A. S. M. Prabandari^1,*, I. B. G. T. Y. Yatindra², N. N. S. P. Sari³, A. I. W. Harimawan¹, I. W. Weta¹, N. K. Sumartini¹, I. W. G. Sutadarma¹, S. A. Awan¹

¹Department of Clinical Nutrition, Udayana University/Ngoerah Hospital, ²Department of Urology, Airlangga University/Soetomo Hospital, ³Faculty of Medicine, Udayana University/Ngoerah Hospital, Denpasar, Indonesia

Rationale: Ginger (Zingiber officinale) is a medicinal plant widely used in Indonesia, known for its antioxidant and anti-inflammatory properties. This study aimed to investigate the nephroprotective potential of ginger extract in preventing paracetamol-induced kidney damage in male Wistar rats.

Methods: A true experimental study with a post-test only control group design was conducted on 30 male Wistar rats, randomly divided into five groups: sham, control (paracetamol-induced), and three treatment groups receiving ginger extract at concentrations of 10 mg/mL, 20 mg/mL, and 30 mg/mL for 30 days. On day 30, all groups except sham were administered paracetamol (1,350 mg/kg BW intraperitoneally). Kidney histological damage was assessed on day 30 using hematoxylin-eosin staining and scored based on cellular changes in the proximal tubules. Statistic analysis was performed using One-way ANOVA in SPSS software.

Results: Mean histological damage scores were: sham (76.2), control (153.6), 10 mg/mL (119.4), 20 mg/mL (92.6), and 30 mg/mL (101.2). One-way ANOVA showed significant differences among groups (p < 0.05). Post-hoc analysis revealed all ginger-treated groups had significantly lower damage scores than the control, with the 20 mg/mL group showing the most optimal protective effect (mean difference = 61.0; p < 0.05). No significant difference was found between the 20 mg/mL and 30 mg/mL groups.

Conclusion: Ginger extract demonstrates significant nephroprotective activity against paracetamol-induced kidney injury in rats, with the 20 mg/mL concentration showing the most effective response. These findings support further development of ginger as a natural nephroprotective agent. Future studies are recommended using purified extracts or isolated active compounds.

Disclosure of Interest: None declared