O036 - ORGANIC FOOD CONSUMPTION AND DIET QUALITY IN PREGNANCY ARE NOT ASSOCIATED WITH PEDIATRIC INFLAMMATORY BOWEL DISEASE IN OFFSPRING

O036

ORGANIC FOOD CONSUMPTION AND DIET QUALITY IN PREGNANCY ARE NOT ASSOCIATED WITH PEDIATRIC INFLAMMATORY BOWEL DISEASE IN OFFSPRING

O. M. Anneberg^1,*, S. F. Olsen^2,3, A. V. Hansen¹, A. A. Bjerregaard^2,4, Þ. I. Halldórsson^2,5, T. Jess^1,6, M. B. De Freitas¹

¹Center for Molecular Prediction of Inflammatory Bowel Disease – PREDICT, Aalborg University, ²Center for Fetal Programming, Statens Serum Institut, Copenhagen, Denmark, ³Department of Nutrition, Harvard TH Chan School of Public Health, Boston, United States, ⁴Center for Clinical Research and Prevention, Copenhagen University Hospital, Copenhagen, Denmark, ⁵Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland, ⁶Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark

Rationale: This study explores the association of maternal organic food consumption and diet quality during pregnancy with risk of pediatric-onset IBD (pIBD) in offspring, including the two disease subtypes Crohn’s disease (CD) and ulcerative colitis (UC).

Methods: Danish pregnant mothers were enrolled in the Danish National Birth Cohort in 1996-2002. Food frequency questionnaires assessed their diets in gestational week 25, and telephone interviews assessed their organic food consumption in gestational week 30. The Healthy Eating Index evaluated diet quality based on adherence to Danish dietary guidelines. Offspring were followed long-term through national patient registries to identify who developed pIBD (≤18 years old). Cox regression examined the association between consumption of organic food and pIBD risk in offspring, taking diet quality into consideration (organic and medium-quality, organic and low-quality, or non-organic and medium-quality compared to non-organic and low-quality diets). Analyses were adjusted for parental IBD diagnosis and maternal educational level, pre-pregnancy body mass index, smoking in pregnancy, supplement use in pregnancy, and antibiotics use in pregnancy.

Results: We included 61,790 singleton mother-child dyads, of which 172 children developed pIBD (CD: 95, UC: 77). Diet with high, compared to low, consumption of organic food during pregnancy was not associated with pIBD risk in offspring (HR: 0.94; 95% CI: 0.68–1.29). A higher diet quality was also not associated with pIBD risk (HR: 0.99; 95% CI: 0.97–1.01). Likewise for offspring’s risk of CD and UC. Combining the two provided similar results.

Conclusion: This large prospective cohort study found no association between organic or higher-quality diets in pregnancy and offspring’s risk of pIBD. However, other maternal dietary habits may still play a role.

Disclosure of Interest: O. M. Anneberg: None declared, S. F. Olsen: None declared, A. V. Hansen: None declared, A. A. Bjerregaard: None declared, Þ. I. Halldórsson: None declared, T. Jess Consultant for: Ferring and Pfizer., M. B. De Freitas: None declared