P499 - IMPACT OF RENAL BIOMARKERS ON SARCOPENIA AND FRAILTY IN PATIENTS WITH LIVER CIRRHOSIS

P499

IMPACT OF RENAL BIOMARKERS ON SARCOPENIA AND FRAILTY IN PATIENTS WITH LIVER CIRRHOSIS

W. Sohn^1,*, J. H. Kim², J.-Y. Cho³, J. Y. Jeong⁴

¹Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, ²Hallym University Dongtan Sacred Heart Hospital, Dongtan, ³Chosun University Hospital, Gwang-Ju, ⁴Ewha Womans University College of Medicine, Seoul, Korea, Republic Of

Rationale: This study was to investigate the role of renal biomarkers on sarcopenia and frailty in patients with liver cirrhosis.

Methods: A total of 78 cirrhotic patients with serum creatinine <1.5 mg/dL were analysed with serum renal biomarkers (creatinine-to-cystatin C ratio, IL-18, KIM-1, and NGAL), sarcopenia, and liver frailty index (LFI). Sarcopenia was defined as a skeletal muscle index less than 36.54 cm²/m² (male) and 30.21 cm²/m² (female), respectively. LFI composed 3 performance-based tests (grip strength, chair stands, and balance). We analysed the risk of sarcopenia and frailty according to a variety of renal biomarkers in patients with cirrhosis.

Results: The mean age was 59.2 years and females was 32%. Child-Pugh class A and B were 82% and 18%, respectively. Sarcopenia, pre-frail, and frail were observed in 43 patients (55.1%). There was no significant difference in serum IL-18 (205.8 vs. 236.7 pg/mL, p=0.285), NGAL (110.8 vs. 104.3 ng/mL, p=0.537), and KIM-1 (224.6 vs. 250.5 pg/mL, p=0.482) according to sarcopenia and frailty. However, serum creatinine-to-cystatin C ratio was significantly lower in patients with sarcopenia and frailty compared to no sarcopenia and frailty (0.73 vs. 0.83, p=0.002). A univariable analysis showed that sarcopenia and frailty were associated with age ≥60 years [odds ratio (OR) 2.42, p=0.06], female (OR 2.88, p=0.043), Child-Pugh class B (OR 14.73, p=0.012), and creatinine-to-cystatin C ratio <0.8 (OR 5.59, p=0.001). A multivariable analysis indicated that the risk factors for sarcopenia and frailty were Child-Pugh class B (OR 9.04, p=0.044), and creatinine-to-cystatin C ratio <0.8 (OR 4.03, p=0.008). Serum IL-18, NGAL, and KIM-1 were not associated with sarcopenia and frailty.

Conclusion: Serum creatinine-to-cystatin C ratio is associated with an increased risk of sarcopenia and frailty in cirrhotic patients with favourable renal function.

Disclosure of Interest: None declared