PD392 - EFFECT OF DIETARY INTERVENTIONS ON PHASE ANGLE IN PATIENTS WITH CHRONIC KIDNEY DISEASE UNDERGOING DIALYSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

PD392

EFFECT OF DIETARY INTERVENTIONS ON PHASE ANGLE IN PATIENTS WITH CHRONIC KIDNEY DISEASE UNDERGOING DIALYSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

N. T. Bellafronte^1,*, C. Frizzas¹, N. R. Almeida², P. D. O. Lübke³, E. I. Rabito¹, N. T. Bellafronte¹

¹Nutrition, Federal University of Paraná, ²Nutrition, Santa Casa de Misericórdia de Curitiba, Curitiba, ³Nutrition, Municipal Health Department of São José dos Pinhais, São José dos Pinhais, Brazil

Rationale: Phase angle (PhA) is inversely associated with malnutrition, a common condition in chronic kidney disease CKD) managed through dietary therapy. Although evidence from oncology and sports field suggests that nutritional interventions may improve PhA, supporting its potential use as a marker of therapeutic efficacy, data from CKD remains limited. We conducted a systematic review with meta-analysis on the effects of diet-related interventions on PhA in patients with CKD undergoing dialysis.

Methods: PubMed, Scopus, Web of Science, CINAHL and Embase were searched until September 3, 2025. Eligible clinical trials included individuals (≥ 18 y) with CKD undergoing dialysis, applying an unimodal or multimodal intervention with a dietetic component as compared to control, and reporting PhA changes. Meta-analysis was conducted; stratification according to intervention details was applied.

Results: A total of 14 studies (RCT, n = 9) comprising 969 participants were included in the review. Overall, there is no influence of dietetic intervention accompanied or not by an exercise-related component, compared to standard of care (i.e., no intervention), on PhA values (mean difference=0.22; 95%CI, -0.20 to 0.63; p<0.001; I²=78%), nor does the isolated effect of the dietary component (mean difference=0.26; 95%CI, -0.22 to 0.73; p<0.001; I²=80%), as well as the use of amino acid or protein-based diet-only intervention (mean difference=0.49; 95%CI, -0.19 to 1.17; p<0.001; I²=73%). The risk of bias was high in two, moderate in six, and low in one RCT; among non-randomized studies, risk of bias was high in three, serious in one, and low in one study.

Conclusion: Our meta-analysis found no effect of dietary interventions on PhA in CKD patients undergoing dialysis. However, due to small number of RCTs and high risk of bias, further high-quality trials are needed.

Disclosure of Interest: None declared