PD090 - IMPACT OF RESPIRATORY SARCOPENIA ON PROGNOSIS IN HEART FAILURE PATIENTS

PD090

IMPACT OF RESPIRATORY SARCOPENIA ON PROGNOSIS IN HEART FAILURE PATIENTS

J. D. De la Borda-Paredes^1,*, D. González-Islas², A. Orea-Tejeda², R. Sánchez-Santillán², L. Ramírez-Morales², D. Bonilla-Cuatepotzo², K. García-Díaz², V. Maldonado-Vargas², G. Cruz-Gijón², G. Rentería-Serralde², G. Benítez-Moya², E. Vargas-Corona², B. Valderrábano-Salas², J. Ruan-Díaz², S. Alday-Ramirez²

¹Facultad de Estudios Superiores Zaragoza , Universidad Nacional Autónoma de México, ²Unidad Clínica de Investigación Cardiopulmonar y Metabólica. Servicio de Cardiología, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Ciudad de México, Mexico

Rationale: Heart failure (HF) is a syndrome caused by structural and/or functional heart anomalies with increase intracardiac pressures and/or low cardiac output. (1) Respiratory sarcopenia (RS) is a generalized process with respiratory muscles decline, reducing oxygenation and multisystemic organic deterioration secondary to hypoxia (2) Respiratory failure increases the risk of cardiovascular diseases (2) The objective of this study was to evaluate the impact of RS prognosis in HF patients.

Methods: A cross-sectional study was conducted in patients >18 years with a confirmed diagnosis of HF. Patients hospitalized within the 3 months previous were excluded. RS was diagnosed by spirometry if expiratory peak flow  <4.4 in women and <3.21 in men. Comparisons between study groups were performed using X² for qualitative variables and T-student for quantitative variables. The risk of death was assessed using adjusted logistic regression.

Results: Of the 140 patients evaluated, had 8.57% RS; 65.71% were men, mean age was 63.89± 13.52 years, 65.47% had hypertension, 50.71% diabetes and 23.91% Obstructive Sleep Apnea (OSA). Patients with RS showed a lower prevalence of hypertension (25 vs 69.29, p= 0.002), diabetes (16.67 vs 53.91, p=0.014) and OSA (0 vs 26.19, p=0.042).

Pulmonary function of patients with RS had lower FEV1 (1.12 ± 0.45 vs. 2.29 ± 0.75, p < 0.001) and FEV1/FVC (0.55 ± 0.20 vs. 0.79 ± 0.09, p< 0.001) than subjects without SR. Patients with SR had 10 fold risk of death (OR: 10.37, 95% CI: 1.34 to 79.98, p=0.025) compared with subjects without SR, adjusting for confounding variables.

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Conclusion: The RS is a risk factor to death in patients with HF.

References: 1. Jorge-Huerta L, Marco-Alacid, et. Alabama.Narrative Review of the Diagnosis and Treatment of Sarcopenia and Malnutrition in Patients with Heart Failure.Nutrientes.2024;16(16):2717

2. Loyola WS, Sérgio PP, Probst VS. Mecanismos fisiopatológicos de la sarcopenia en la EPOC.2019;35(2):124–32

Disclosure of Interest: None declared