Sep 13, 2025
1:00 PM2:00 PM
Poster Session
P117 - CROSS-SECTIONAL ASSESSMENT OF BODY COMPOSITION AND MUSCLE FUNCTION IN CROHN'S DISEASE PATIENTS, STRATIFIED BY PRESENCE AND EXTENT OF INTESTINAL RESECTION
P117
CROSS-SECTIONAL ASSESSMENT OF BODY COMPOSITION AND MUSCLE FUNCTION IN CROHN'S DISEASE PATIENTS, STRATIFIED BY PRESENCE AND EXTENT OF INTESTINAL RESECTION
G. Becherucci1,*, L. Parisio 1, F. Profeta1, E. Foscarini 1, C. Covello 2, A. Del Gaudio 2, F. Di Vincenzo 2, J. Iaccarino 2, M. Pizzoferrato 3, V. Petito 4, L. Masi 4, S. Troisi 4, C. Pane 4, V. Calvez1, L. Laterza1, F. De Biasio 1, C. Marmo 1, I. Mignini 1, L. Turchini 1, V. Amatucci 1, L. N. Giordano 1, L. R. Lopetuso 1, A. Gasbarrini 5, M. C. Mentella 1, A. Papa6, F. Scaldaferri 1
1Digestive Disease Center CeMAD- Dipartimento di Scienze Mediche e Chirurgiche, 2Univeristà Cattolica Del Sacro Cuore, Fondazione Policlinico A.Gemelli IRCCS, IBD Unit, 3Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico A.Gemelli IRCCS, UOC Gastroenterologia, 4Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico A.Gemelli IRCCS, CeMAD Translational Research Laboratories, 5Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico A.Gemelli IRCCS, UOC Medicina Interna e Gastroenterologia- Digestive Disease Center CeMAD, 6Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico A.Gemelli IRCCS, UOSD DH Medicina Interna e Malattie dell’Apparato Digerente, Rome, Italy
Rationale: Crohn'sdisease(CD)isamajorcauseofshortbowelsyndrome(SBS),whichcanleadtointestinal failure(IF).SBSisoftenlinkedtosarcopenia,affectingqualityoflifeandincreasing complicationrisks.ThisstudyaimedtoevaluatedifferencesinbodycompositionandmusclestrengthamongCDpatientsatvaryingrisklevelsforSBS.
Methods: Weconductedacross-sectionalstudywithconsecutiveCDoutpatients.GroupAincludedpatientswithSBSorwhohadundergonetwoormorebowelresectionsoroneresectionover50cm. GroupBconsistedofpatientswhohadnosurgeryoroneresectionunder50cm. Bodycompositionwasassessedbybioimpedanceanalysis(BIA),musclestrengthviahandgriptest,and eatinghabitsusingafoodfrequencyquestionnaire. Statisticalanalyses,includingt-testsorMann-Whitneytests,wereperformedwithasignificancethresholdofp<0.05.
Results: The study cohort included 150 patients (mean age 53 years [±19,2]; 24% female). Group A showed an average BMI of 23,7±4 kg/m2, whereas group B showed an average BMI of 24.6±5 kg/m2.Muscle strength measured between groups was reduced in group A showing significant differences in hand grip test compared to group B (p-value<0.001).However, no significant differences were observed in muscle mass or in eating habits across groups.
Conclusion: Our study revealed that SBS and CD patients resected two or more times or with a resection greater than 50 cm had reduced muscle strength without a corresponding reduction in muscle mass, indicating impaired muscle function. FurtherresearchisneededtobetterunderstandtherelationshipbetweenCD-relatedresectionsandtheirimpacton musclequalityandquantity.Fundedby:2.1"Rafforzamentoepotenziamentodellaricercabiomedicadel SSN",finanziatodall’Unione europea–NextGenerationEU,CUPC53C22001140007.2022PNRRProject "Changingthefutureofintestinalfailureinintestinalchronicinflammation:towardsinnovativepredictivefactorsandtherapeutictargets"code:PNRR-MAD-2022-12376791
Disclosure of Interest: None declared