PP385 - IS TUBE FEEDING FEASIBLE IN PATIENTS UNDERGOING A STEM CELL TRANSPLANTATION?

PP385

IS TUBE FEEDING FEASIBLE IN PATIENTS UNDERGOING A STEM CELL TRANSPLANTATION?

M. Somer^1,*, A. Kok¹, S. Baauw²

¹Dietetics, University Medical Center Utrecht, Utrecht, ²Wageningen University, Wageningen, Netherlands

Rationale: The ESPEN guidelines recommend enteral nutrition (EN) as the first-line intervention in patients undergoing a stem cell transplantation (SCT). Despite clear advantages of EN, parenteral nutrition (TPN) is still widely used as first-choice intervention. Our aim was to asses the feasibility of tube feeding (TF) in SCT patients.

Methods: In this retrospective study, 200 haemato-oncology patients undergoing a SCT were included. Data from medical charts were used to assess tube feeding and TPN prescription during and after hospitalization, indications, nutritional adequacy, timing, duration and weight. Adherence to ESPEN guidelines was assessed by the presence of ESPEN-defined criteria in patients receiving TPN. Severe mucositis was defined as CTCAE grade ≥2 or the use of an analgesia pump. Severe malabsorption and protracted diarrhea was defined as > 1000ml watery diarrhea.

Results: In this study 22% of Allogeneic and 32% of Auto SCT patients received TF during hospitalization. TPN was administered to 22% of Allo SCT patients and 6% of Auto SCT patients. Among all TPN users, 81% met at least one ESPEN-defined criterion. TF indications were low oral intake, no appetite and nausea, while TPN was primarily initiated due to low oral intake, severe oral mucositis or transitioning from TF. 71% of Allo SCT and 75% of Auto SCT receiving TF achieved ≥75% of prescribed nutritional goals, with no significant differences between SCT groups, was started on average at day +11 in Allo SCT patients (~16 days) and day +8 in Auto SCT patients (~19 days). In both groups, TPN was initiated around day +11 (~9-11 days). Weightloss in Allo SCT patients was 3% at discharge and 5% at follow-up, in Auto SCT patients 3% at discharge, 4% at follow-up with very little difference between TF en TPN.

Conclusion: This study shows that it is feasible to use tube feeding in high adherence to ESPEN guidelines, with consistently adequate nutritional support.

Disclosure of Interest: None declared