PP224 - PREVALENCE, DIAGNOSIS AND FACTORS ASSOCIATED WITH SARCOPENIC OBESITY (SO): A CROSS-SECTIONAL OBSERVATIONAL RETROSPECTIVE STUDY IN A REFERENCE CENTER

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PP224

PREVALENCE, DIAGNOSIS AND FACTORS ASSOCIATED WITH SARCOPENIC OBESITY (SO): A CROSS-SECTIONAL OBSERVATIONAL RETROSPECTIVE STUDY IN A REFERENCE CENTER

J. Develay1, M. Guiho1, E. Rageul1, M. Barrallier1, R. Pflaum1, H. Pisaroni1, A. Durous1, M. Fichet1, R. Thibault1,2,*

1Endocrinology-Diabetology-Nutrition, CHU Rennes, 2Nutrition, Metabolisms and Cancer (NuMeCan), INRAE, INSERM, Univ Rennes, Rennes, France

 

Rationale: SO diagnostic criteria lack validation. Aims: to determine and compare SO prevalence according to different diagnostic methods (primary), assess the diagnostic performance of dry fat-free mass (dFFM) and phase angle and identify factors associated with SO (secondary).

Methods: We recruited patients consulting for obesity at our centre. Data were collected (2021-2024): bioclinical, handgrip strength, body composition (bioimpedance analysis). Statistics: SO prevalence between methods (1-3), ROC curves, Youden method, multivariate logistic regression.

Results: N=244 patients: 77% F, age, 41.2±12.4 yr, BMI, 42.6±6.1, 16 (6.6%) had SO according to the EASO & ESPEN method (1)), 18.1% using handgrip adjusted for age and sex <10th percentile (2), 4.1%, using the fat mass index (FMI) to fat-free mass index (FFMI) ratio (3). SO cutoffs in women, dFFM <13.8 kg  (AUC=0.78 [0.62–0.93], sensitivity 88.9%, specificity 59.2%, positive (P) predictive value (PV) 9.9%, negative (N)PV 99.1%), and phase angle <7.1° (AUC=0.72 [95% confidence interval, 0.57–0.86], sensitivity 100%, specificity 38.6%, PPV 7.6%, NPV 100%). SO (1) risk factors: male sex (odds ratio (OR)=13.73 [2.75–68.47], P=0.001), vitamin B12 plasma concentrations (OR=6.08 [1.07–34.63], P=0.04), fat-free mass (OR=0.82 [0.70–0.96], P=0.01). Using (2), only phase angle was negatively correlated with SO (OR=0.77 [0.62–0.95], P=0.01).

Conclusion: In patients with severe obesity, the prevalence of SO according to the ESPEN-EASO consensus (1) is 6.6%. We suggest new tools for diagnosing SO that are simple and more accessible for daily practice.

References: (1) Donini et al, Obesity Facts 2021; (2) Dodds, PLoS one 2014; (3) Xiao, Clin Nutr 2018

Disclosure of Interest: None declared