PD200 - NUTRIGENETIC INFLUENCE OF CYP4F2 RS2108622 ON VITAMIN E STATUS IN A HIGHLY ADMIXED BRAZILIAN POPULATION

PD200

NUTRIGENETIC INFLUENCE OF CYP4F2 RS2108622 ON VITAMIN E STATUS IN A HIGHLY ADMIXED BRAZILIAN POPULATION

M. L. Costa^1,*, M. Macedo Rogero¹, C. Hermes Sales¹, F. Mori Sarti¹, R. M. Fisberg¹

¹Nutrition Department, University of São Paulo, São Paulo, Brazil

Rationale: Vitamin E (α-tocopherol) status is influenced by dietary intake and genetics. The CYP4F2 rs2108622 (C>T; p.V433M) polymorphism is associated with α-tocopherol concentration, but its effects in admixed populations and interactions with diet remain unclear. We evaluated the association between rs2108622 with plasma vitamin E and whether dietary intake modifies this effect in a Brazilian population.

Methods: We analyzed data from 567 adults and older adults in the ISA-Nutrition study. Plasma α-tocopherol was measured via HPLC. Habitual dietary intake was estimated by two 24-hour recalls using the MSM software and energy-adjusted. The rs2108622 variant was genotyped (HWE p=0.65; MAF=0.25). Linear regression (dominant model: CC vs. T-allele) was adjusted for age, sex, and genomic ancestry . Intake was categorized by the median for stratified analyses.

Results: Median plasma vitamin E was 18.20 µmol/L, and median intake was 6.0 mg/day. T-allele carriers had significantly higher plasma vitamin E than CC individuals (β=1.79 µmol/L; p<0.01). Dietary intake alone was not significantly associated with plasma levels. Stratified analyses showed significant genotype associations in the high-intake group (p<0.01).

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Conclusion: The CYP4F2 rs2108622 polymorphism is associated with plasma vitamin E in a highly admixed Brazilian population. CC individuals exhibit lower vitamin E concentrations independent of dietary intake. These results underscore the importance of accounting for CYP4F2 variation in nutrigenomic research to optimize vitamin E status across diverse populations.

Disclosure of Interest: None declared