PD246 - IMPACT OF COMORBIDITIES ON NUTRITIONAL SUPPORT DELIVERY AND OUTCOMES IN CRITICALLY ILL PATIENTS

PD246

IMPACT OF COMORBIDITIES ON NUTRITIONAL SUPPORT DELIVERY AND OUTCOMES IN CRITICALLY ILL PATIENTS

D. Yánez^1,2,*, L. Gonzalez¹, V. Villamar², N. Cool², J. Abrigo²

¹Universidad Católica de Santiago de Guayaquil, ²Hospital General Guasmo Sur, Guayaquil, Ecuador

Rationale: Comorbidities may influence nutritional support delivery and clinical outcomes in critically ill patients, requiring optimized individualized strategies in the intensive care unit (ICU).

Methods: An analytical cross-sectional study was conducted in an adult ICU in Ecuador (2024). Adult patients (≥18 years) with ICU stay >24 hours receiving nutritional support were included. Outcomes included ICU mortality, length of stay, and complications. Statistical analysis used Chi-square/Fisher’s exact test, Student’s t-test or Mann–Whitney U test, and logistic regression, with p<0.05 considered significant.

Results: A total of 600 patients were included. Hypertension (26.2%) and diabetes mellitus (26.8%) were the most frequent comorbidities. Early nutritional support was achieved in 63.0%, while 37.0% had delayed initiation and 76.3% required interruption. ICU mortality was 1.8%. Delayed initiation was associated with hypertension (p=0.001), diabetes mellitus (p<0.001), and chronic kidney disease (CKD) (p=0.031). Interruption of nutritional support was associated with diabetes mellitus (p<0.001). In multivariable analysis, diabetes mellitus remained independently associated with delayed initiation (p=0.021) and interruption (p<0.001). Diabetes mellitus was also associated with ICU length of stay (p=0.037), while overall comorbidity burden showed no association with outcomes.

Conclusion: Specific comorbidities, particularly diabetes mellitus, were independently associated with delayed initiation and interruption of nutritional support, as well as ICU length of stay. Overall comorbidity burden was not associated with nutritional support delivery or outcomes, supporting individualized strategies based on specific conditions.

Disclosure of Interest: None declared