PD221 - NUTRITIONAL FACTORS ASSOCIATED WITH MORTALITY IN CRITICALLY ILL PATIENTS

PD221

NUTRITIONAL FACTORS ASSOCIATED WITH MORTALITY IN CRITICALLY ILL PATIENTS

A. García García^1,2,*, H. Pozo Romero², D. D. L. R. Rodríguez González³, E. Sánchez Sánchez⁴, M. J. Muñoz Alférez⁵, A. Úbeda Iglesias²

¹INiBICA - Instituto de Investigación e Innovación Biomédica de Cádiz, ²Servicio de Medicina Intensiva, Hospital Universitario Punta de Europa, Algeciras, ³Centro de Salud La Línea Centro - La Velada, La Línea de la Concepción, ⁴Departamento de Enfermería y Fisioterapia, Facultad de Enfermería, Universidad de Cádiz, Algeciras, ⁵Departamento de Fisiología, Universidad de Granada, Granada, Spain

Rationale: Malnutrition and sarcopenia are common in critically ill patients and linked to poor outcomes and mortality. This study aims to identify nutritional factors related to mortality in ICU patients and emphasize early nutritional and morphofunctional assessment.

Methods: Prospective observational cohort study in a single ICU including adult critically ill patients with ICUstay>24h (June2024–November2025). Variables:demographics, CONUT, lab data, bioimpedance, muscle ultrasound, admission diagnosis, ICU/hospital stay, mortality, 15-day follow-up. Categorical: frequencies(%); quantitative:mean±SD or median(IQR). Comparisons:chi-square/Fisher and Mann–Whitney U tests. Multivariate logistic regression and ROC analysis(p<.05). EthicsCommittee of Cádiz approved; informed consent obtained. No COI.

Results: 104 patients were included. Survivors were compared with non-survivors at 15 days. Age(64.8[59–73] vs 71.2[60–78.75],p=.04), APACHE II(13.31[8.5–18]vs21.24[15–27],p<.01),SOFA(3.3[1–5] vs 7.38[5–10],p<.01), mechanical ventilation(26.8% vs 68.2%,p<.01),duration of ventilation(0.50[0–1] vs 1.14[0–2],p<.01), handgrip(15.89[2–27.3] vs 4.59[0–4.25],p<.01), SARC-F(4.9[3–8]vs 6.95[8–8],p<.01), CONUT(5[1–8.5] vs 7.88[6–10], p<.01), albumin(3.29[2.7–4]vs2.81[2.43–2.98],p=.01), leukocytes(10.8[6.9–12.7] vs 17.4[11.1–20.2],p<.01), neutrophils(8.5[4.7–10.2]vs15.1[9.6–16.7],p<.01). Multivariate analysis: SARC-F(OR 1.60;95%CI 1.10–2.64), creatinine(OR 2.13;95%CI 1.21–4.41), albumin(OR 0.27;95%CI 0.07–0.80), abdominal adipose tissue(OR 0.08;95%CI 0.01–0.51) associated with mortality. ROC AUC=0.91(95%CI 0.84–0.98).

Conclusion: Nutritional and functional status at ICU admission was associated with mortality in critically ill patients. Poorer nutritional status, higher sarcopenia risk and worse functional status identified patients with worse prognosis, highlighting the importance of early nutritional and continuous morphofunctional assessment in the ICU.

Disclosure of Interest: None declared