P454 - EVALUATION OF THE RISK OF SARCOPENIA IN INDIVIDUALS DIAGNOSIS OF MASLD

P454

EVALUATION OF THE RISK OF SARCOPENIA IN INDIVIDUALS DIAGNOSIS OF MASLD

A. Aydin^1,*, A. I. Hatemi²

¹Nutrition and Dietetics, Istanbul Okan University, ²Gastroenterology, Istanbul University-Cerrahpasa, Istanbul, Türkiye

Rationale: Hepatic steatosis,which is characterized by hepatic triglyceride accumulation and also affects muscle tissue, can trigger metabolic changes by reducing muscle mass and impairing its function.Identifying MASLD risk factors such as sarcopenia could help early intervention and reduce the burden of the disease.

Methods: The study aimed to determine the sarcopenia risk of MASLD individuals and compare them with anthropometric characteristics and blood parameters.A total of 100 individuals with MASLD diagnosis (abdominal ultrasonography),hepatitis diagnosis who were followed up by Istanbul University-Cerrahpaşa Medical Faculty Hospital Gastroenterology Polyclinic were included.Anthropometric measurements, of the patients and blood parameters were compared according to the presence of sarcopenia risk(SARC-F). 

Results: SARC-F score of 7 patients with MASLD and 11 patients with hepatitis was found to be ≥4.The mean hand grip strength of individuals with MASLD at risk of sarcopenia was 26.3±7.2, while it was 20.4±5.1 in individuals with hepatitis at risk of sarcopenia.There were no significant differences in blood parameters and anthropometric measurements between individuals with MASLD and hepatitis who had a SARC-F ≥4.A moderate positive correlation was found between age and SARC-F score for all three groups (p<0.001; r=0.402).A moderate negative correlation was found between SARC-F score and handgrip strength in individuals with MASLD and hepatitis(p<0.001; r=-0.469).Results on the participants are shown in Table 1.

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Conclusion: In conclusion,sarcopenia risk was detected in 14% of individuals with MASLD, and in 22% of individuals with hepatitis.There were no statistically significant differences in average handgrip strength and blood parameters between individuals with MASLD and hepatitis who were at risk of sarcopenia.

References: Crişan,D. et al.(2025)Sarcopenia in MASLD-Eat to Beat Steatosis,Move to Prove Strength.Nutrients,17(1),178

Disclosure of Interest: None declared