P266 - ASSOCIATION BETWEEN EXTENDED INFLAMMATORY PARAMETERS (EIP) AND NUTRITIONAL STATUS IN PATIENTS WITH ESOPHAGEAL DISORDERS.

P266

ASSOCIATION BETWEEN EXTENDED INFLAMMATORY PARAMETERS (EIP) AND NUTRITIONAL STATUS IN PATIENTS WITH ESOPHAGEAL DISORDERS.

P. Kutnik^1,*, M. Drabik², J. Dziedzic³, D. Helena², C. Prado⁴

¹Faculty of Medicine, Institute of Medical Sciences, The John Paul II Catholic University of Lublin, ²Department of Laboratory Diagnostics, University Clinical Hospital No. 1 , ³2nd Department of General and Gastrointestinal Surgery, and Surgical Oncology of the Alimentary Tract, Medical University of Lublin, Lublin, Poland, ⁴Department of Agricultural, Food and Nutritional Science,, University of Alberta, Edmonton, Canada

Rationale: Malnutrition and inflammation are often connected, and frequently present in patients with esophageal disorders. This study assesses the association between EIP and nutritional status in these patients.

Methods: This prospective observational study was approved by the bioethical committee and included patients with hiatus hernia esophagus (HH), achalasia (A), esophageal cancer (EC), and esophageal stricture (ES). Patient demographics and routine laboratory test results were collected. EIP included neutrophile reactivity intensity (NEUT-RI), and neutrophile granularity intensity (NEUT-GI) assessed during total blood count analysis. Nutritional status was evaluated by GLIM criteria. 

Results: The study included 102 patients (HHO = 30, A = 16, EC = 27, ES = 29); 36.3% had malnutrition (HHO = 10%, A = 43.8%, EC = 59.3%, ES = 37.9%, p = .01). Weight and BMI were lower in malnourished patients (80 vs 69 kg, p < .001, and 27.24 vs 23.29 kg/m², p < .001). NEUT-GI was higher in malnourished patients (155.1 vs 152.2 p = .012), NEUT-RI was not different between these two groups (p = .16). Lymphocytes, neutrophile-lymphocyte ratio (NLR), and CRP approached statistical significance (p = .072, p = .059, and p = .052, respectively). When comparing across primary conditions, NEUR-RI differed significantly (HH) 47.4; A: 48.6; EC: 49.3; ES: 45.8; p = .0018), as did body weight, BMI, NLR, and CRP (p = .0017, p < .001, p = .01, p = .04, respectively). NEUT-GI showed no association with primary condition (p = .3).

Conclusion: This study showed an association between NEUT-GI and nutritional status, and NEUT-RI and different types of esophageal disorders. Further studies are needed to determine whether these findings can be used to assess inflammation pathways involved in malnutrition and esophageal disorders.

Disclosure of Interest: None declared