P396 - ASSOCIATION BETWEEN CT-DERIVED SKELETAL MUSCLE MASS AND SHORT- AND LONG-TERM MORTALITY IN CRITICALLY ILL PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS

P396

ASSOCIATION BETWEEN CT-DERIVED SKELETAL MUSCLE MASS AND SHORT- AND LONG-TERM MORTALITY IN CRITICALLY ILL PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS

V. A. Bertoni Maluf¹, F. R. Herrmann², A. Platon³, A. Mendes², Y. M. Dupertuis¹, A. de Watteville^4,*, C. P. Heidegger^4,⁵, L. Genton¹

¹Departement of Medicine , ²Department of Rehabilitation and Geriatrics, ³Department of Radiology, ⁴Depatement of Acute Care Medicine, Geneva University Hospitals, ⁵Department of anaesthesiology, pharmacology, intensive care and emergency medicine, University of Geneva, Geneva, Switzerland

Rationale: Low skeletal muscle mass is associated with poor clinical outcomes. This systematic review and meta-analysis examines the relationship between CT-derived skeletal muscle mass at the lumbar spine and short- and long-term mortality in critically ill patients.

Methods: Studies involving critically ill adults (≥18 years) admitted to intensive care units (ICUs) and assessing CT-derived skeletal muscle mass at the lumbar level within ±7 days of admission were included following PRISMA 2020 guidelines. Mortality outcomes were categorized as short-term (ICU, hospital, 28- and 30-day) and long-term (beyond 30 days). Searches were conducted in MEDLINE and Embase without date restrictions. Study selection utilized Rayyan, data extraction followed a custom-designed tool, and quality assessment was performed using the JBI Cohort Study Checklist. Meta-analysis compared mortality outcomes between in patients with preserved versus reduced skeletal muscle mass.

Results: From 1248 records, 18 studies (5233 participants) were included. Skeletal muscle mass was mostly reported as skeletal muscle mass at L3. Short-term mortality (28 or 30 days) was the most common outcome presented in 18 studies; long-term mortality (90 days, 6 months, 1 year) was assessed in 5 studies. Meta-analyses showed that reduced muscle mass was associated with higher short-term (OR = 2.28, CI: 1.79–2.91, I² = 46.28%) and long-term mortality (OR = 3.02, CI: 1.40–6.51, I² = 67.83%).

Conclusion: CT-assessed lumbar muscle mass is linked to mortality in ICU patients. Establishing standardized measurement protocols and cut-off values for low muscle mass at L3 is essential to enhance reliability and comparability across studies. Future research should prioritize interventions to mitigate muscle loss in this high-risk population.

Disclosure of Interest: None declared