PD059 - SARCOPENIA AND FLUID IMBALANCES IN PATIENTS AT INTERMEDIATE-TO-HIGH RISK PULMONARY HYPERTENSION.

PD059

SARCOPENIA AND FLUID IMBALANCES IN PATIENTS AT INTERMEDIATE-TO-HIGH RISK PULMONARY HYPERTENSION.

G. Cruz-Gijón^1,2,*, N. Hernández-López ², D. González-Islas ², A. Orea-Tejeda², B. Valderrábano-Salas ², G. Rentería-Serralde ², G. Benítez-Moya ², E. Vargas-Corona ², J. De la Borda-Paredes², L. Ramirez-Morales², D. Bonilla-Cuatepotzo², K. García-Díaz ², V. Maldonado-Vargas², J. Ruan-Díaz², S. Alday-Ramírez², R. Sanchez-Santillan²

¹Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México., ²Unidad Clínica de Investigación Cardiopulmonar y Metabólica, Servicio de Cardiología. , Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Ciudad de México , Mexico

 

Rationale: Pulmonary hypertension (PH) is a progressive condition characterized by elevated pulmonary arterial pressure, leading to right ventricular overload and eventual heart failure (1,2). Fluid imbalance and sarcopenia are both associated with worse clinical outcomes, but their relationship in PH patients remains insufficiently understood (3). This study aimed to determine the prevalence of sarcopenia and fluid imbalance in patients with intermediate-to-high risk PH.

Methods: A cross-sectional study was conducted in patients older than 18 years with intermediate-to-high risk PH, defined by tricuspid regurgitation velocity between >2.9 m/s. Sarcopenia was defined according to EWGSOP2 criteria, and body composition and fluid distribution were assessed using bioelectrical impedance analysis. Comparisons between study groups were performed using the chi-square (χ²) test for qualitative variables and Student’s t-test for quantitative variables.

Results: A total of 210 patients were included; 10.47% had sarcopenia. Mean age was 72.18 ± 12.83 years, and 45.71% were women. 50% had systemic hypertension, 33 % diabetes, 38.57% COPD and 64.76% heart failure. Patients with sarcopenia had lower BMI and muscle strength, also higher total fluid accumulation and ECW (p < 0.05). Pulmonary function (FVC) was lower in the sarcopenia group (p = 0.036).

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Conclusion: Sarcopenia is prevalent in patients with intermediate-to-high risk PH and is associated with fluid retention, particularly increased ECW.

References:  

Simonneau G, et al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J. 2019;53(1):1801913. 

Humbert M, Kovacs G, et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2022;43(38):3618–3731.

Galiè N, Humbert M, et al. 2015 ESC/ERS Guidelines for pulmonary hypertension. Eur Heart J. 2016;37(1):67–119.

Disclosure of Interest: None declared