PT06 - DIETARY INFLAMMATORY POTENTIAL AND CARDIOVASCULAR-KIDNEY-METABOLIC SYNDROME: INSIGHTS FROM 19,883 US ADULTS

PT06

DIETARY INFLAMMATORY POTENTIAL AND CARDIOVASCULAR-KIDNEY-METABOLIC SYNDROME: INSIGHTS FROM 19,883 US ADULTS

J. Zhu^1,*, Q. Lyu^1,2

¹First affiliated hospital of zhengzhou university, ²School of Public Health, Zhengzhou University, Zhengzhou, China

Rationale: Growing evidence implicates poor cardiovascular-kidney-metabolic (CKM) health as a leading driver of early morbidity and mortality, with diet-induced inflammation emerging as a potential contributor. This study examined the relationship between the Dietary Inflammatory Index (DII) and CKM syndrome to address this critical gap.

Methods: We analyzed data from 19,883 adults participating in the 1999–2018 National Health and Nutrition Examination Survey (NHANES). Survey-weighted multinomial logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs) for DII associations across CKM stages, with stage 0 as the referent. Associations with advanced CKM (stages 3–4) were assessed using weighted logistic regression, dose-response relationships via restricted cubic splines, and mediation analysis to evaluate systemic inflammation biomarkers.

Results: Higher DII scores were consistently associated with elevated odds of progressive CKM stages. Compared with the lowest DII quartile, participants in the highest quartile had significantly greater odds of CKM stage 1 (OR, 1.52; 95% CI, 1.46–1.59), stage 2 (OR, 1.75; 95% CI, 1.67–1.84), stage 3 (OR, 1.91; 95% CI, 1.90–1.93), and stage 4 (OR, 2.67; 95% CI, 2.55–2.80). Similarly, the highest DII quartile was associated with increased likelihood of advanced CKM syndrome (OR, 1.56; 95% CI, 1.26–1.92). Dose-response analysis demonstrated a non-linear, positive association between DII scores and advanced CKM risk, with each one-point increase in DII corresponding to a 9% higher odds of advanced CKM syndrome (OR, 1.09; 95% CI, 1.04–1.13). 

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Conclusion: Higher dietary inflammatory potential is associated with with greater prevalence and severity of CKM syndrome. These findings suggest that dietary modulation of inflammatory pathways may offer a promising strategy to reduce systemic inflammation and alleviate the burden of CKM-related morbidity.

Disclosure of Interest: None declared