Sep 7, 2026
12:30 PM2:00 PM
ePoster presentations
PP367 - HANDGRIP STRENGTH AND SPPB ARE ASSOCIATED WITH EFFLUENT UV TOXIN LOAD IN HAEMODIALYSIS: SEX-SPECIFIC PATTERNS AND 12-WEEK FOLLOW-UP
PP367
HANDGRIP STRENGTH AND SPPB ARE ASSOCIATED WITH EFFLUENT UV TOXIN LOAD IN HAEMODIALYSIS: SEX-SPECIFIC PATTERNS AND 12-WEEK FOLLOW-UP
J. C. González Oliva1,*, A. Roda Safont1, V. Duarte Gallego1, J. Ugalde Altamirano1, K. Pasache Chong1, A. Rovira Algara1, V. Cazorla Rodríguez1, J. Calls Ginesta1, C. Guzmán Rodríguez1
1Nephrology, Hospital de Mollet, Mollet del Valles, Spain
Rationale: Whether standard functional and nutritional markers predict real-time effluent UV toxin load in haemodialysis, and whether this association depends on sex and albumin status, is unknown.
Methods: Retrospective observational study with prospective 12-week follow-up including 1,046 haemodialysis sessions in 61 patients (November 2025–April 2026). Handgrip strength, Short Physical Performance Battery (SPPB) and Malnutrition Inflammation Score (MIS) were available in 48 patients; albumin in 971 sessions (47 patients). The Metabolic Efficiency Score (MES) was derived from the Nikkiso DDM 285 nm sensor. Spearman correlations and subgroup analyses by sex and albumin stratum were performed.
Results: Handgrip was associated with MES overall (ρ = 0.360; n = 300; p < 0.001) and in sessions with albumin ≥3.5 g/dL (ρ = 0.371; n = 276; p < 0.001), but not when albumin < 3.5 g/dL. In men, handgrip was associated with MES (ρ = 0.218; n = 201; p = 0.002). In women, SPPB showed the strongest association (ρ = −0.684; p < 0.001). MIS correlated with albumin (ρ = −0.429; p < 0.001) and prealbumin (ρ = −0.415; p < 0.001). Handgrip declined over 12 weeks (Δ = −1.4 kg; p = 0.002).
Conclusion: The association between functional markers and effluent UV toxin load is sex-specific and was observed only in sessions with adequate albumin status. Hypoalbuminaemia appears to disrupt functional–metabolic coupling. Progressive handgrip decline reinforces its value as a prognostic marker in haemodialysis.
Disclosure of Interest: None declared